Contribution of mitochondria to pain in diabetic neuropathy

Natalia Hernández-Beltrán, Carlos B. Moreno, ángela María Gutiérrez-álvarez

Research output: Contribution to journalShort survey

8 Citations (Scopus)

Abstract

Diabetes is a metabolic disease affecting approximately 300 million people worldwide. Neuropathy is one of its frequent complications, and may affect sensory, motor, and autonomic nerves. Its pathophysiology has not fully been elucidated. Several hypotheses have been proposed, and mitochondria have been suggested to play a significant role. This article reviews the mechanisms involved in mitochondrial dysfunction and development of diabetic neuropathy, consisting mainly of oxidative and inflammatory stress, changes in intracellular calcium regulation, apoptotic processes, and changes in mitochondrial structure and function that may lead to development of diabetic neuropathy. © 2011 SEEN.
Original languageEnglish (US)
Pages (from-to)25-32
Number of pages8
JournalEndocrinologia y Nutricion
DOIs
StatePublished - Jan 1 2013

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Diabetic Neuropathies
Mitochondria
Autonomic Pathways
Pain
Metabolic Diseases
Oxidative Stress
Calcium

Cite this

Hernández-Beltrán, N., Moreno, C. B., & Gutiérrez-álvarez, Á. M. (2013). Contribution of mitochondria to pain in diabetic neuropathy. Endocrinologia y Nutricion, 25-32. https://doi.org/10.1016/j.endonu.2012.03.005
Hernández-Beltrán, Natalia ; Moreno, Carlos B. ; Gutiérrez-álvarez, ángela María. / Contribution of mitochondria to pain in diabetic neuropathy. In: Endocrinologia y Nutricion. 2013 ; pp. 25-32.
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Contribution of mitochondria to pain in diabetic neuropathy. / Hernández-Beltrán, Natalia; Moreno, Carlos B.; Gutiérrez-álvarez, ángela María.

In: Endocrinologia y Nutricion, 01.01.2013, p. 25-32.

Research output: Contribution to journalShort survey

TY - JOUR

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AU - Hernández-Beltrán, Natalia

AU - Moreno, Carlos B.

AU - Gutiérrez-álvarez, ángela María

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N2 - Diabetes is a metabolic disease affecting approximately 300 million people worldwide. Neuropathy is one of its frequent complications, and may affect sensory, motor, and autonomic nerves. Its pathophysiology has not fully been elucidated. Several hypotheses have been proposed, and mitochondria have been suggested to play a significant role. This article reviews the mechanisms involved in mitochondrial dysfunction and development of diabetic neuropathy, consisting mainly of oxidative and inflammatory stress, changes in intracellular calcium regulation, apoptotic processes, and changes in mitochondrial structure and function that may lead to development of diabetic neuropathy. © 2011 SEEN.

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JO - Endocrinologia, Diabetes y Nutricion

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