TY - JOUR
T1 - Contribution of mitochondria to pain in diabetic neuropathy
AU - Hernández-Beltrán, Natalia
AU - Moreno, Carlos B.
AU - Gutiérrez-álvarez, ángela María
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Diabetes is a metabolic disease affecting approximately 300 million people worldwide. Neuropathy is one of its frequent complications, and may affect sensory, motor, and autonomic nerves. Its pathophysiology has not fully been elucidated. Several hypotheses have been proposed, and mitochondria have been suggested to play a significant role. This article reviews the mechanisms involved in mitochondrial dysfunction and development of diabetic neuropathy, consisting mainly of oxidative and inflammatory stress, changes in intracellular calcium regulation, apoptotic processes, and changes in mitochondrial structure and function that may lead to development of diabetic neuropathy. © 2011 SEEN.
AB - Diabetes is a metabolic disease affecting approximately 300 million people worldwide. Neuropathy is one of its frequent complications, and may affect sensory, motor, and autonomic nerves. Its pathophysiology has not fully been elucidated. Several hypotheses have been proposed, and mitochondria have been suggested to play a significant role. This article reviews the mechanisms involved in mitochondrial dysfunction and development of diabetic neuropathy, consisting mainly of oxidative and inflammatory stress, changes in intracellular calcium regulation, apoptotic processes, and changes in mitochondrial structure and function that may lead to development of diabetic neuropathy. © 2011 SEEN.
U2 - 10.1016/j.endonu.2012.03.005
DO - 10.1016/j.endonu.2012.03.005
M3 - Short survey
SN - 2530-0164
SP - 25
EP - 32
JO - Endocrinologia, Diabetes y Nutricion
JF - Endocrinologia, Diabetes y Nutricion
ER -
