Contribution of mitochondria to pain in diabetic neuropathy

Natalia Hernández-Beltrán, Carlos B. Moreno, ángela María Gutiérrez-álvarez

Research output: Contribution to journalShort surveypeer-review

14 Scopus citations

Abstract

Diabetes is a metabolic disease affecting approximately 300 million people worldwide. Neuropathy is one of its frequent complications, and may affect sensory, motor, and autonomic nerves. Its pathophysiology has not fully been elucidated. Several hypotheses have been proposed, and mitochondria have been suggested to play a significant role. This article reviews the mechanisms involved in mitochondrial dysfunction and development of diabetic neuropathy, consisting mainly of oxidative and inflammatory stress, changes in intracellular calcium regulation, apoptotic processes, and changes in mitochondrial structure and function that may lead to development of diabetic neuropathy. © 2011 SEEN.
Original languageEnglish (US)
Pages (from-to)25-32
Number of pages8
JournalEndocrinologia y Nutricion
DOIs
StatePublished - Jan 1 2013

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