Complejo esclerosis tuberosa

Translated title of the contribution: Tuberous sclerosis complex

Alberto Velez-van-Meerbeke, Carlos Medina-Malo, Orlando Carreño, Luis Arturo Lizcano, León Darío Ortiz, Henry Becerra, Andrés Felipe Cardona

Research output: Contribution to journalResearch Articlepeer-review

10 Scopus citations

Abstract

IntroductIon: The Tuberous Sclerosis Complex (TSC) is the mainstay of malformation related to alterations in cellular growth and differentiation, with highly variable phenotypes, and systemic impact.

ObjectIve: To characterize and describe TSC to facilitate understanding of the neurodermatosis in the Colombian population.

MaterIals and Methods: Information was obtained from searches performed in MEDLINE, BIOSIS, and EMBASE from 1966, 1994 and 1974, respectively, until March 1, 2011, using the OVID platform and multiple key terms. Additional strategies were designed for other databases like LILACS, CINAHL and Best Evidence using similar criteria. We also collected data from scientific societies related to the topic under study.

Results: the diagnostic criteria have not been modified instead molecular characterizations leads to a better understanding of the disease. The characterization of pathogenesis leads to the development of target therapies against those molecular alterations. mTOR pathway explains phenotypic alterations in patients suffering of TSC.

ConclusIon: the document of the Colombian Consensus for the Neurodermathosis, wants to show an integral review of the knowledge about the development, diagnosis and treatment of TSC.

KEY WORDS. Tuberous Sclerosis, Astrocytoma, TOR Serine-Treonine Kinasas, Biological Therapy (MeSH).
Translated title of the contributionTuberous sclerosis complex
Original languageSpanish
Pages (from-to)11 - 23
Number of pages12
JournalActa Neurológica Colombiana
Volume28
StatePublished - 2012

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