Coinfection Suspicion is Imperative in Immunosuppressed Patients with Suspected Infectious Uveitis and Inadequate Treatment Response: A Case Report

Germán Mejía-Salgado; Catalina Cardozo-Pérez; Carlos Cifuentes-González; Claudia Durán-Merino; Alejandra de-la-Torre

doi:10.1080/09273948.2024.2367656

Coinfection Suspicion is Imperative in Immunosuppressed Patients with Suspected Infectious Uveitis and Inadequate Treatment Response: A Case Report

Germán Mejía-Salgado, Catalina Cardozo-Pérez, Carlos Cifuentes-González, Claudia Durán-Merino, Alejandra de-la-Torre

Research output: Contribution to Journal › Research Article › peer-review

1 Scopus citations

Abstract

Background: To report a case of coinfection of Toxoplasma gondii (Tg) and Epstein Barr Virus (EBV) in a diabetic patient with rheumatoid arthritis and immunosuppressive biological therapy.

Case presentation: A 70-year-old female with a history of rheumatoid arthritis on therapy with corticosteroids, methotrexate, and abatacept presented bilateral granulomatous panuveitis associated with retinal necrosis and macular involvement. A diagnostic vitrectomy detected Tg and EBV. Treatment with clindamycin, trimethoprim-sulfamethoxazole, and acyclovir was established, achieving improvement.

Conclusions: Patients undergoing immunosuppressive therapy are at risk of developing opportunistic infections, often presenting with severe and atypical clinical manifestations. In such cases, multiplex polymerase chain reaction is an invaluable diagnostic tool that helps identify the specific pathogens involved. This enables healthcare professionals to make informed treatment decisions and provide targeted therapy for each identified pathogen.

Translated title of the contribution	La sospecha de coinfección es imperativa en pacientes inmunodeprimidos con sospecha de uveítis infecciosa y respuesta inadecuada al tratamiento: Informe de un caso
Original language	English (US)
Pages (from-to)	2548-2552
Number of pages	5
Journal	Ocular Immunology and Inflammation
Volume	32
Issue number	10
DOIs	https://doi.org/10.1080/09273948.2024.2367656
State	Published - Dec 2024

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Ophthalmology

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10.1080/09273948.2024.2367656

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title = "Coinfection Suspicion is Imperative in Immunosuppressed Patients with Suspected Infectious Uveitis and Inadequate Treatment Response: A Case Report",

abstract = "Background: To report a case of coinfection of Toxoplasma gondii (Tg) and Epstein Barr Virus (EBV) in a diabetic patient with rheumatoid arthritis and immunosuppressive biological therapy.Case presentation: A 70-year-old female with a history of rheumatoid arthritis on therapy with corticosteroids, methotrexate, and abatacept presented bilateral granulomatous panuveitis associated with retinal necrosis and macular involvement. A diagnostic vitrectomy detected Tg and EBV. Treatment with clindamycin, trimethoprim-sulfamethoxazole, and acyclovir was established, achieving improvement.Conclusions: Patients undergoing immunosuppressive therapy are at risk of developing opportunistic infections, often presenting with severe and atypical clinical manifestations. In such cases, multiplex polymerase chain reaction is an invaluable diagnostic tool that helps identify the specific pathogens involved. This enables healthcare professionals to make informed treatment decisions and provide targeted therapy for each identified pathogen.",

author = "Germ{\'a}n Mej{\'i}a-Salgado and Catalina Cardozo-P{\'e}rez and Carlos Cifuentes-Gonz{\'a}lez and Claudia Dur{\'a}n-Merino and Alejandra de-la-Torre",

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language = "English (US)",

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Coinfection Suspicion is Imperative in Immunosuppressed Patients with Suspected Infectious Uveitis and Inadequate Treatment Response: A Case Report. / Mejía-Salgado, Germán; Cardozo-Pérez, Catalina; Cifuentes-González, Carlos et al.
In: Ocular Immunology and Inflammation, Vol. 32, No. 10, 12.2024, p. 2548-2552.

Research output: Contribution to Journal › Research Article › peer-review

TY - JOUR

T1 - Coinfection Suspicion is Imperative in Immunosuppressed Patients with Suspected Infectious Uveitis and Inadequate Treatment Response

T2 - A Case Report

AU - Mejía-Salgado, Germán

AU - Cardozo-Pérez, Catalina

AU - Cifuentes-González, Carlos

AU - Durán-Merino, Claudia

AU - de-la-Torre, Alejandra

PY - 2024/12

Y1 - 2024/12

N2 - Background: To report a case of coinfection of Toxoplasma gondii (Tg) and Epstein Barr Virus (EBV) in a diabetic patient with rheumatoid arthritis and immunosuppressive biological therapy.Case presentation: A 70-year-old female with a history of rheumatoid arthritis on therapy with corticosteroids, methotrexate, and abatacept presented bilateral granulomatous panuveitis associated with retinal necrosis and macular involvement. A diagnostic vitrectomy detected Tg and EBV. Treatment with clindamycin, trimethoprim-sulfamethoxazole, and acyclovir was established, achieving improvement.Conclusions: Patients undergoing immunosuppressive therapy are at risk of developing opportunistic infections, often presenting with severe and atypical clinical manifestations. In such cases, multiplex polymerase chain reaction is an invaluable diagnostic tool that helps identify the specific pathogens involved. This enables healthcare professionals to make informed treatment decisions and provide targeted therapy for each identified pathogen.

AB - Background: To report a case of coinfection of Toxoplasma gondii (Tg) and Epstein Barr Virus (EBV) in a diabetic patient with rheumatoid arthritis and immunosuppressive biological therapy.Case presentation: A 70-year-old female with a history of rheumatoid arthritis on therapy with corticosteroids, methotrexate, and abatacept presented bilateral granulomatous panuveitis associated with retinal necrosis and macular involvement. A diagnostic vitrectomy detected Tg and EBV. Treatment with clindamycin, trimethoprim-sulfamethoxazole, and acyclovir was established, achieving improvement.Conclusions: Patients undergoing immunosuppressive therapy are at risk of developing opportunistic infections, often presenting with severe and atypical clinical manifestations. In such cases, multiplex polymerase chain reaction is an invaluable diagnostic tool that helps identify the specific pathogens involved. This enables healthcare professionals to make informed treatment decisions and provide targeted therapy for each identified pathogen.

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DO - 10.1080/09273948.2024.2367656

M3 - Research Article

C2 - 38889439

AN - SCOPUS:85196269423

SN - 0927-3948

VL - 32

SP - 2548

EP - 2552

JO - Ocular Immunology and Inflammation

JF - Ocular Immunology and Inflammation

IS - 10

ER -

Coinfection Suspicion is Imperative in Immunosuppressed Patients with Suspected Infectious Uveitis and Inadequate Treatment Response: A Case Report

Abstract

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