Coexpression network analysis identified lncRNAs-mRNAs with potential relevance in African ancestry prostate cancer

Rafael Parra-Medina, Liliana López-Kleine, Sandra Ramírez-Clavijo, César Payán-Gómez

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: This study aims to investigate similarities and differences using lncRNA and mRNA coexpression network analysis in African ancestry (AA) and European ancestry (EA) among prostate cancer (PCa) patients. Methods: We performed weighted gene coexpression network analysis of the expression from 49 of AA and 49 of EA to identify lncRNAs-mRNAs. Results: 27 lncRNAs and 36 mRNAs were highly expressed in patients of AA. Two mRNAs and their antisense lncRNAs were expressed. Additionally, seven mRNAs were DE or coexpressed and had an impact on survival. Conclusion: We present a list of lncRNAs and mRNAs that were DE and coexpressed when comparing patients of AA and EA, and these data are a resource for future studies to understand the role of lncRNAs.

Original languageEnglish (US)
Article numberFSO749
JournalFuture Science OA
Volume7
Issue number9
DOIs
StatePublished - Oct 2021

All Science Journal Classification (ASJC) codes

  • Biotechnology

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