Cloning, expression, and characterisation of a Plasmodium vivax MSP7 family merozoite surface protein

Alvaro Mongui; Oscar Perez-Leal; Sara C. Soto; Jimena Cortes; Manuel A. Patarroyo

doi:10.1016/j.bbrc.2006.10.082

Cloning, expression, and characterisation of a Plasmodium vivax MSP7 family merozoite surface protein

Alvaro Mongui
, Oscar Perez-Leal
, Sara C. Soto
, Jimena Cortes
, Manuel A. Patarroyo

Research output: Contribution to Journal › Research Article › peer-review

22 Scopus citations

Abstract

Plasmodium vivax remains the most widespread Plasmodium parasite specie around the world, producing about 75 million malaria cases, mainly in South America and Asia. A vaccine against this disease is of urgent need, making the identification of new antigens involved in target cell invasion, and thus potential vaccine candidates, a priority. A protein belonging to the P. vivax merozoite surface protein 7 (PvMSP7) family was identified in this study. This protein (named PvMSP71) has 311 amino acids displaying an N-terminal region sharing high identity with P. falciparum MSP7, as well as a similar proteolytical cleavage pattern. This protein's expression in P. vivax asexual blood stages was revealed by immuno-histochemical and molecular techniques. © 2006 Elsevier Inc. All rights reserved.

Translated title of the contribution	Clonación, expresión y caracterización de una proteína de superficie del merozoito de la familia MSP7 de Plasmodium vivax
Original language	English (US)
Pages (from-to)	639-644
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	351
Issue number	3
DOIs	https://doi.org/10.1016/j.bbrc.2006.10.082
State	Published - Dec 22 2006

All Science Journal Classification (ASJC) codes

Immunology and Allergy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbrc.2006.10.082

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title = "Cloning, expression, and characterisation of a Plasmodium vivax MSP7 family merozoite surface protein",

abstract = "Plasmodium vivax remains the most widespread Plasmodium parasite specie around the world, producing about 75 million malaria cases, mainly in South America and Asia. A vaccine against this disease is of urgent need, making the identification of new antigens involved in target cell invasion, and thus potential vaccine candidates, a priority. A protein belonging to the P. vivax merozoite surface protein 7 (PvMSP7) family was identified in this study. This protein (named PvMSP71) has 311 amino acids displaying an N-terminal region sharing high identity with P. falciparum MSP7, as well as a similar proteolytical cleavage pattern. This protein's expression in P. vivax asexual blood stages was revealed by immuno-histochemical and molecular techniques. {\textcopyright} 2006 Elsevier Inc. All rights reserved.",

author = "Alvaro Mongui and Oscar Perez-Leal and Soto, \{Sara C.\} and Jimena Cortes and Patarroyo, \{Manuel A.\}",

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doi = "10.1016/j.bbrc.2006.10.082",

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TY - JOUR

T1 - Cloning, expression, and characterisation of a Plasmodium vivax MSP7 family merozoite surface protein

AU - Mongui, Alvaro

AU - Perez-Leal, Oscar

AU - Soto, Sara C.

AU - Cortes, Jimena

AU - Patarroyo, Manuel A.

PY - 2006/12/22

Y1 - 2006/12/22

N2 - Plasmodium vivax remains the most widespread Plasmodium parasite specie around the world, producing about 75 million malaria cases, mainly in South America and Asia. A vaccine against this disease is of urgent need, making the identification of new antigens involved in target cell invasion, and thus potential vaccine candidates, a priority. A protein belonging to the P. vivax merozoite surface protein 7 (PvMSP7) family was identified in this study. This protein (named PvMSP71) has 311 amino acids displaying an N-terminal region sharing high identity with P. falciparum MSP7, as well as a similar proteolytical cleavage pattern. This protein's expression in P. vivax asexual blood stages was revealed by immuno-histochemical and molecular techniques. © 2006 Elsevier Inc. All rights reserved.

AB - Plasmodium vivax remains the most widespread Plasmodium parasite specie around the world, producing about 75 million malaria cases, mainly in South America and Asia. A vaccine against this disease is of urgent need, making the identification of new antigens involved in target cell invasion, and thus potential vaccine candidates, a priority. A protein belonging to the P. vivax merozoite surface protein 7 (PvMSP7) family was identified in this study. This protein (named PvMSP71) has 311 amino acids displaying an N-terminal region sharing high identity with P. falciparum MSP7, as well as a similar proteolytical cleavage pattern. This protein's expression in P. vivax asexual blood stages was revealed by immuno-histochemical and molecular techniques. © 2006 Elsevier Inc. All rights reserved.

U2 - 10.1016/j.bbrc.2006.10.082

DO - 10.1016/j.bbrc.2006.10.082

M3 - Research Article

C2 - 17081497

SN - 0006-291X

VL - 351

SP - 639

EP - 644

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 3

ER -

Cloning, expression, and characterisation of a Plasmodium vivax MSP7 family merozoite surface protein

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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