Clinical Insights: Antimicrobial Therapy for Infectious Uveitis

Evangeline Leong, Carlos Cifuentes-González, Jeremy Hu Y. W, Ramar Perumal Samy, Moncef Khairallah, William Rojas-Carabali, Ikhwanuliman Putera, Alejandra de-la-Torre, Rupesh Agrawal

Research output: Contribution to journalReview articlepeer-review


Infectious uveitis is a major global cause of vision impairment. Despite the eye’s immune privilege, afforded by the blood-ocular barrier that restricts microbial entry, several pathogens such as bacteria, viruses, fungi, and parasites can still infiltrate and cause ocular infections and complications. Clinicians often encounter significant challenges in treating infectious uveitis due to limited or ineffective treatment options. Modern molecular techniques and imaging can aid in diagnosing and assessing intraocular infections. Various antimicrobial therapies exist, spanning topical and systemic treatments, but these are constrained by issues like drug concentration, penetration, effective duration, toxicity, and side effects. Treatment approaches also differ based on the infection’s etiology. This review provides recent updates on antimicrobial therapies from a clinical perspective, covering topical, systemic, and regional treatments for infectious uveitis.

Original languageEnglish (US)
JournalOcular Immunology and Inflammation
StateAccepted/In press - 2024
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Ophthalmology


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