Clinical and Serological Characteristics of Ocular Toxoplasmosis in the Democratic Republic of Congo

Nadine Nsiangani Lusambo; Dieudonné Kaimbo Wa Kaimbo; Dieudonné Mumba Ngoyi; Janvier Kilangalanga Ngoy; Marie Thérèse Ngoyi Bambi; Théodore Kadima Mutombo; Guy Kintoki Makela; Lady Ngandowe Nzamokili; Alejandra de-la-Torre

doi:10.1080/09273948.2022.2140297

Clinical and Serological Characteristics of Ocular Toxoplasmosis in the Democratic Republic of Congo

Nadine Nsiangani Lusambo
, Dieudonné Kaimbo Wa Kaimbo
, Dieudonné Mumba Ngoyi
, Janvier Kilangalanga Ngoy
, Marie Thérèse Ngoyi Bambi
, Théodore Kadima Mutombo
, Guy Kintoki Makela
, Lady Ngandowe Nzamokili
, Alejandra de-la-Torre

Research output: Contribution to Journal › Research Article › peer-review

5 Scopus citations

Abstract

PURPOSE: To describe demographic data, clinical features, and serological profiles in a cohort of Congolese patients with ocular toxoplasmosis (OT).

METHOD: Cross-sectional study, carried out between March 2020 and July 2021 in two ophthalmic clinics in Kinshasa.

RESULTS: The study comprised 95 participants with OT. Fifty-three patients were male (55.8%). The mean age at presentation was 35.6 ± 14.1 years (range 8-69 years); 71 had active OT (74.7%), among them, 33 had primary OT (46.5%), and 38 had recurrences (53.5%). At presentation, 51 patients (53.7%) had visual impairment (VA < 6/18). Retinochoroidal lesions were located in the central retina in 60 patients (63.1%). Patients with primary OT tend to have higher IgG levels than those with recurrent OT ( P = .01).

CONCLUSION: We report the largest cohort of patients with OT in sub-Saharan Africa. In our setting, most patients had recurrent OT with multiple, extensive, and central retinochoroidal lesions.

Original language	English (US)
Pages (from-to)	1-6
Number of pages	6
Journal	Ocular Immunology and Inflammation
Volume	31
Issue number	7
DOIs	https://doi.org/10.1080/09273948.2022.2140297
State	Published - Nov 3 2022

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All Science Journal Classification (ASJC) codes

Immunology and Allergy
Ophthalmology

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10.1080/09273948.2022.2140297

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Nsiangani Lusambo, N., Kaimbo Wa Kaimbo, D., Mumba Ngoyi, D., Kilangalanga Ngoy, J., Ngoyi Bambi, M. T., Kadima Mutombo, T., Kintoki Makela, G., Ngandowe Nzamokili, L., & de-la-Torre, A. (2022). Clinical and Serological Characteristics of Ocular Toxoplasmosis in the Democratic Republic of Congo. Ocular Immunology and Inflammation, 31(7), 1-6. https://doi.org/10.1080/09273948.2022.2140297

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title = "Clinical and Serological Characteristics of Ocular Toxoplasmosis in the Democratic Republic of Congo",

abstract = "PURPOSE: To describe demographic data, clinical features, and serological profiles in a cohort of Congolese patients with ocular toxoplasmosis (OT).METHOD: Cross-sectional study, carried out between March 2020 and July 2021 in two ophthalmic clinics in Kinshasa.RESULTS: The study comprised 95 participants with OT. Fifty-three patients were male (55.8\%). The mean age at presentation was 35.6 ± 14.1 years (range 8-69 years); 71 had active OT (74.7\%), among them, 33 had primary OT (46.5\%), and 38 had recurrences (53.5\%). At presentation, 51 patients (53.7\%) had visual impairment (VA < 6/18). Retinochoroidal lesions were located in the central retina in 60 patients (63.1\%). Patients with primary OT tend to have higher IgG levels than those with recurrent OT ( P = .01). CONCLUSION: We report the largest cohort of patients with OT in sub-Saharan Africa. In our setting, most patients had recurrent OT with multiple, extensive, and central retinochoroidal lesions.",

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Nsiangani Lusambo, N, Kaimbo Wa Kaimbo, D, Mumba Ngoyi, D, Kilangalanga Ngoy, J, Ngoyi Bambi, MT, Kadima Mutombo, T, Kintoki Makela, G, Ngandowe Nzamokili, L & de-la-Torre, A 2022, 'Clinical and Serological Characteristics of Ocular Toxoplasmosis in the Democratic Republic of Congo', Ocular Immunology and Inflammation, vol. 31, no. 7, pp. 1-6. https://doi.org/10.1080/09273948.2022.2140297

TY - JOUR

T1 - Clinical and Serological Characteristics of Ocular Toxoplasmosis in the Democratic Republic of Congo

AU - Nsiangani Lusambo, Nadine

AU - Kaimbo Wa Kaimbo, Dieudonné

AU - Mumba Ngoyi, Dieudonné

AU - Kilangalanga Ngoy, Janvier

AU - Ngoyi Bambi, Marie Thérèse

AU - Kadima Mutombo, Théodore

AU - Kintoki Makela, Guy

AU - Ngandowe Nzamokili, Lady

AU - de-la-Torre, Alejandra

PY - 2022/11/3

Y1 - 2022/11/3

N2 - PURPOSE: To describe demographic data, clinical features, and serological profiles in a cohort of Congolese patients with ocular toxoplasmosis (OT).METHOD: Cross-sectional study, carried out between March 2020 and July 2021 in two ophthalmic clinics in Kinshasa.RESULTS: The study comprised 95 participants with OT. Fifty-three patients were male (55.8%). The mean age at presentation was 35.6 ± 14.1 years (range 8-69 years); 71 had active OT (74.7%), among them, 33 had primary OT (46.5%), and 38 had recurrences (53.5%). At presentation, 51 patients (53.7%) had visual impairment (VA < 6/18). Retinochoroidal lesions were located in the central retina in 60 patients (63.1%). Patients with primary OT tend to have higher IgG levels than those with recurrent OT ( P = .01). CONCLUSION: We report the largest cohort of patients with OT in sub-Saharan Africa. In our setting, most patients had recurrent OT with multiple, extensive, and central retinochoroidal lesions.

AB - PURPOSE: To describe demographic data, clinical features, and serological profiles in a cohort of Congolese patients with ocular toxoplasmosis (OT).METHOD: Cross-sectional study, carried out between March 2020 and July 2021 in two ophthalmic clinics in Kinshasa.RESULTS: The study comprised 95 participants with OT. Fifty-three patients were male (55.8%). The mean age at presentation was 35.6 ± 14.1 years (range 8-69 years); 71 had active OT (74.7%), among them, 33 had primary OT (46.5%), and 38 had recurrences (53.5%). At presentation, 51 patients (53.7%) had visual impairment (VA < 6/18). Retinochoroidal lesions were located in the central retina in 60 patients (63.1%). Patients with primary OT tend to have higher IgG levels than those with recurrent OT ( P = .01). CONCLUSION: We report the largest cohort of patients with OT in sub-Saharan Africa. In our setting, most patients had recurrent OT with multiple, extensive, and central retinochoroidal lesions.

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SN - 0927-3948

VL - 31

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JO - Ocular Immunology and Inflammation

JF - Ocular Immunology and Inflammation

IS - 7

ER -

Clinical and Serological Characteristics of Ocular Toxoplasmosis in the Democratic Republic of Congo

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