Circulation of Streptococcus pneumoniae clone Colombia5 ST289 in nine Latin American countries

Carolina Firacative, Jaime Moreno, Patricia Resales, Aurora Maldonado, Jacqueline Sánchez, Carmen Pesantes, Sergio López, Markela De Quinzada, Gustavo Chamorro, Sara Morales, Enza Spadola, Jean Marc Gabastou, Elizabeth Castañeda

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Objective. To determine genetic relatedness of clone Colombia5 ST289 with invasive Streptococcus pneumoniae serotype 5 isolates recovered in nine Latin American countries. Methods. Forty-four invasive S. pneumoniae serotype 5 isolates recovered from children under 5 years of age in Bolivia, Chile, Dominican Republic, Ecuador, Nicaragua, Panama, Paraguay, Peru, and Venezuela were studied. Pulsed-field gel electrophoresis patterns of DNA treated with Smal restriction enzyme were classified using Tenover's criteria and analyzed with the Fingerprinting II program to determine their genetic relatedness with the Colombian clone. Results. All isolates had a genetic similarity of 78.5% or more with the Colombian clone. Thirteen electrophoretic subtypes derived of pattern A were identified, and five of them (A5, A6, A8, A13, All) comprised 61.4% of the isolates. Conclusions. Clone Colombia 5 ST289 is disseminated in Latin America. This is important because S. pneumoniae serotype 5 frequently causes invasive disease in the region and is associated with trimethoprim-sulfamethoxazole resistance.

Original languageEnglish (US)
Pages (from-to)337-343
Number of pages7
JournalRevista Panamericana de Salud Publica/Pan American Journal of Public Health
Volume25
Issue number4
DOIs
StatePublished - Apr 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

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