Chronic intrathecal baclofen administration in severe spasticity

J. Broseta, G. Garcia-March, M. J. Sánchez-Ledesma, J. Anaya, I. Silva

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


On the basis of previous experimental and clinical studies, 14 patients with severe spasticity due to central or spinal cord damage, resistant to all conservative treatments, were selected after a percutaneous trial period for chronic intrathecal baclofen infusion by programmable pumps. The agent was delivered at C4 in quadriplegic patients or in cases with central spasticity and in the neighbouring areas on the affected segments in paraplegic patients. The daily baclofen dose varied from 25 to 260 pg and was infused in a bolus, continuously infused or both combined according to the results during the trial period. After a mean follow-up period of 11 months, constant decrease of rigidity, absence of spasms, improvement of bladder function, cramping pain remission, and moderate improvement in walking capacity and transfer activities were usually observed. Neither complications nor side effects were noted.

Original languageEnglish (US)
Pages (from-to)147-153
Number of pages7
JournalStereotactic and Functional Neurosurgery
Issue number1-8
StatePublished - 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology


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