Changes in oxygenation levels precede changes in amplitude of the EEG in premature infants

Alexander Caicedo, Liesbeth Thewissen, Anne Smits, Gunnar Naulaers, Karel Allegaert, Sabine Van Huffel

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations

Abstract

Brain function is supported by an appropriate balance between the metabolic demand and the supply of nutrients and oxygen. However, the physiological principles behind the regulation of brain metabolism and demand in premature infants are unknown. Some studies found that changes in hemodynamic variables in this population precede changes in EEG activity; however, these studies only used descriptive statistics. This paper describes the relationship between changes in cerebral oxygenation, assessed by means of near-infrared spectroscopy (NIRS), and changes in EEG, using mathematical methods taken from information dynamics. In a cohort of 35 neonates subjected to sedation by propofol, we quantified the direction of information transfer between brain oxygenation and EEG. The results obtained indicate that, as reported in other studies, changes in NIRS are likely to precede changes in EEG activity.

Original languageEnglish (US)
Title of host publicationOxygen Transport to Tissue XXXVIII
EditorsDuane F. Bruley, Qingming Luo, Lin Z. Li, Hua Shi, David K. Harrison, Duane F. Bruley
PublisherSpringer New York LLC
Pages143-149
Number of pages7
ISBN (Print)9783319388083
DOIs
StatePublished - 2016
Event43rd Annual Meeting of the International Society on Oxygen Transport to Tissue, ISOTT 2015 - Wuhan, China
Duration: Jul 11 2015Jul 16 2015

Publication series

NameAdvances in Experimental Medicine and Biology
Volume923
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Conference

Conference43rd Annual Meeting of the International Society on Oxygen Transport to Tissue, ISOTT 2015
CountryChina
CityWuhan
Period7/11/157/16/15

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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