Changes in oxygenation levels precede changes in amplitude of the EEG in premature infants

Alexander Caicedo, Liesbeth Thewissen, Anne Smits, Gunnar Naulaers, Karel Allegaert, Sabine Van Huffel

    Research output: Contribution to journalArticlepeer-review

    9 Scopus citations


    Brain function is supported by an appropriate balance between the metabolic demand and the supply of nutrients and oxygen. However, the physiological principles behind the regulation of brain metabolism and demand in premature infants are unknown. Some studies found that changes in hemodynamic variables in this population precede changes in EEG activity; however, these studies only used descriptive statistics. This paper describes the relationship between changes in cerebral oxygenation, assessed by means of near-infrared spectroscopy (NIRS), and changes in EEG, using mathematical methods taken from information dynamics. In a cohort of 35 neonates subjected to sedation by propofol, we quantified the direction of information transfer between brain oxygenation and EEG. The results obtained indicate that, as reported in other studies, changes in NIRS are likely to precede changes in EEG activity.

    Original languageEnglish (US)
    Pages (from-to)143-149
    Number of pages7
    JournalAdvances in Experimental Medicine and Biology
    StatePublished - 2016
    Event43rd Annual Meeting of the International Society on Oxygen Transport to Tissue, ISOTT 2015 - Wuhan, China
    Duration: Jul 11 2015Jul 16 2015

    All Science Journal Classification (ASJC) codes

    • General Biochemistry, Genetics and Molecular Biology


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