Challenges in the diagnosis and management of acromegaly: a focus on comorbidities

Alin Abreu, Alejandro Pinzón Tovar, Rafael Castellanos, Claudia Milena Gómez Giraldo, Alex Valenzuela, Alejandro Castellanos Pinedo, Doly Pantoja Guerrero, Carlos Alfonso Builes Barrera, Humberto Ignacio Franco, Antônio Ribeiro-Oliveira, Lucio Vilar, Raquel S. Jallad, Felipe Gaia Duarte, Mônica Gadelha, Cesar Luiz Boguszewski, Julio Abucham, Luciana A. Naves, Nina Rosa C. Musolino, Maria Estela Justamante de Faria, Ciliana RossatoMarcello D. Bronstein

Research output: Contribution to journalReview articlepeer-review

101 Scopus citations


Introduction: Acromegaly is a rare, insidious disease resulting from the overproduction of growth hormone (GH) and insulin-like growth factor 1 (IGF-1), and is associated with a range of comorbidities. The extent of associated complications and mortality risk is related to length of exposure to the excess GH and IGF-1, thus early diagnosis and treatment is imperative. Unfortunately, acromegaly is often diagnosed late, when patients already have a wide range of comorbidities. The presence of comorbid conditions contributes significantly to patient morbidity/mortality and impaired quality of life. Methods: We conducted a retrospective literature review for information relating to the diagnosis of acromegaly, and its associated comorbidities using PubMed. The main aim of this review is to highlight the issues of comorbidities in acromegaly, and to reinforce the importance of early diagnosis and treatment. Findings and conclusions: Successful management of acromegaly goes beyond treating the disease itself, since many patients are diagnosed late in disease evolution, they present with a range of comorbid conditions, such as cardiovascular disease, diabetes, hypertension, and sleep apnea. It is important that patients are screened carefully at diagnosis (and thereafter), for common associated complications, and that biochemical control does not become the only treatment goal. Mortality and morbidities in acromegaly can be reduced successfully if patients are treated using a multimodal approach with comprehensive comorbidity management.

Original languageEnglish (US)
Pages (from-to)448-457
Number of pages10
Issue number4
StatePublished - Aug 1 2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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