TY - JOUR
T1 - Chagas disease (Trypanosoma cruzi) and HIV co-infection in Colombia
AU - Hernández, Carolina
AU - Cucunubá, Zulma
AU - Parra, Edgar
AU - Toro, German
AU - Zambrano, Pilar
AU - Ramírez, Juan David
N1 - Funding Information:
This work was supported by Departamento Administrativo Nacional de Ciencia y Tecnología de Colombia “Francisco José de Caldas – COLCIENCIAS” and “Unión Temporal Programa Nacional de Investigación para la prevención, control y tratamiento integral de la enfermedad de Chagas en Colombia” , grant number 380-2011 , code 5014-537-30398.
PY - 2014/9
Y1 - 2014/9
N2 - Chagas disease is a complex zoonotic pathology caused by the kinetoplastid Trypanosoma cruzi. This parasite presents remarkable genetic variability and has been grouped into six discrete typing units (DTUs). The association between the DTUs and clinical outcome remains unknown. Chagas disease and co-infection with HIV/AIDS has been reported widely in Brazil and Argentina. Herein, we present the molecular analyses from a Chagas disease patient with HIV/AIDS co-infection in Colombia who presented severe cardiomyopathy, pleural effusion, and central nervous system involvement. A mixed infection by T. cruzi genotypes was detected. We suggest including T. cruzi in the list of opportunistic pathogens for the management of HIV patients in Colombia. The epidemiological implications of this finding are discussed.
AB - Chagas disease is a complex zoonotic pathology caused by the kinetoplastid Trypanosoma cruzi. This parasite presents remarkable genetic variability and has been grouped into six discrete typing units (DTUs). The association between the DTUs and clinical outcome remains unknown. Chagas disease and co-infection with HIV/AIDS has been reported widely in Brazil and Argentina. Herein, we present the molecular analyses from a Chagas disease patient with HIV/AIDS co-infection in Colombia who presented severe cardiomyopathy, pleural effusion, and central nervous system involvement. A mixed infection by T. cruzi genotypes was detected. We suggest including T. cruzi in the list of opportunistic pathogens for the management of HIV patients in Colombia. The epidemiological implications of this finding are discussed.
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U2 - 10.1016/j.ijid.2014.04.002
DO - 10.1016/j.ijid.2014.04.002
M3 - Article
C2 - 25080354
AN - SCOPUS:84907324107
SN - 1201-9712
VL - 26
SP - 146
EP - 148
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
ER -
