Cerebrovascular autoregulation in preterm fetal growth restricted neonates

Emily Cohen, Willem Baerts, Alexander Caicedo, Gunnar Naulers, Frank van Bel, Petra M A Lemmers

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    20 Scopus citations


    Objective: To investigate the effect of fetal growth restriction (FGR) on cerebrovascular autoregulation in preterm neonates during the first 3 days of life. Design: Case–control study. Setting: Neonatal intensive care unit of the Wilhelmina Children’s Hospital, The Netherlands. Patients: 57 FGR (birth weight <10th percentile) and 57 appropriate for gestational age (AGA) (birth weight 20th–80th percentiles) preterm neonates, matched for gender, gestational age, respiratory and blood pressure support. Methods: The correlation between continuously measured mean arterial blood pressure and regional cerebral oxygen saturation was calculated to generate the cerebral oximetry index (COx). Mean COx was calculated for each patient for each postnatal day. The percentage of time with impaired autoregulation (COx>0.5) was also calculated. Results: FGR neonates had higher mean COx values than their AGA peers on day 2 (0.15 (95% CI 0.11 to 0.18) vs 0.09 (95% CI 0.06 to 0.13), p=0.029) and day 3 (0.17 (95% CI 0.13 to 0.20) vs 0.09 (95% CI 0.06 to 0.12), p=0.003) of life. FGR neonates spent more time with impaired autoregulation (COx value >0.5) than controls on postnatal day 2 (19% (95% CI 16% to 22%) vs 14% (95% CI 12% to 17%), p=0.035) and day 3 (20% (95% CI 17% to 24%) vs 15% (95% CI 12% to 18%), p=0.016). Conclusion: FGR preterm neonates more frequently display impaired cerebrovascular autoregulation compared with AGA peers on days 2 and 3 of life which may predispose them to brain injury. Further studies are required to investigate whether this impairment persists beyond the first few days of life and whether this impairment is linked to poor neurodevelopmental outcome.
    Translated title of the contributionAutoregulación Cerebrovascular en Neonatos Prematuros con Crecimiento Fetal Restringido
    Original languageEnglish (US)
    Pages (from-to)1
    Number of pages6
    JournalArchives of Disease in Childhood: Fetal and Neonatal Edition
    StatePublished - Oct 2018


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