Candida y candidiasis invasora: un reto continuo para su diagnóstico temprano

Translated title of the contribution: Candida and candidiasis: the challenge continues for an early diagnosis

Catalina De Bedout, Beatriz L. Gómez

Research output: Contribution to journalArticlepeer-review


Invasive candidiasis represents 75% of fungal infections in hospitalized patients, with reported mortalities up to 78%. The frequency of these infections varies according to the hospital services and the risk factors of the patients. In parallel, changes in the epidemiology of the Candida species have been observed, in particular variations in their prevalence and in their resistance to antifungals according to geographic location. For these reasons it is crucial to establish an early diagnosis that identifies the pathogen to the species level in order to allow an appropriate therapeutic decision. The diagnosis of invasive candidiasis continues to be a challenge, where combining the different available methods (microbiologic, immunologic and new molecular approaches) is the best strategy to achieve a prompt and accurate diagnosis. We review the currently available assays for conventional and molecular diagnosis, their limitations, and the perspectives for assays that are now in development and validation. In the last decade, well established reference methods have become available for testing antifungal susceptibility and this has allowed worldwide and regional sensitivity profiles to be established for the different Candida species.
Translated title of the contributionCandida and candidiasis: the challenge continues for an early diagnosis
Original languageSpanish (Colombia)
Pages (from-to)159-171
Number of pages12
Issue numberSup.2
StatePublished - Dec 1 2010
Externally publishedYes


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