Blood-brain barrier biomarkers

Juan F. Zapata-Acevedo, Alejandra Mantilla-Galindo, Karina Vargas-Sánchez, Rodrigo E. González-Reyes

Research output: Chapter in Book/ReportChapterResearch

Abstract

The blood-brain barrier (BBB) is a dynamic interface that regulates the exchange of molecules and cells between the brain parenchyma and the peripheral blood. The BBB is mainly composed of endothelial cells, astrocytes and pericytes. The integrity of this structure is essential for maintaining brain and spinal cord homeostasis and protection from injury or disease. However, in various neurological disorders, such as traumatic brain injury, Alzheimer's disease, and multiple sclerosis, the BBB can become compromised thus allowing passage of molecules and cells in and out of the central nervous system parenchyma. These agents, however, can serve as biomarkers of BBB permeability and neuronal damage, and provide valuable information for diagnosis, prognosis and treatment. Herein, we provide an overview of the BBB and changes due to aging, and summarize current knowledge on biomarkers of BBB disruption and neurodegeneration, including permeability, cellular, molecular and imaging biomarkers. We also discuss the challenges and opportunities for developing a biomarker toolkit that can reliably assess the BBB in physiologic and pathophysiologic states.

Translated title of the contributionBiomarcadores de la barrera hematoencefálica
Original languageEnglish (US)
Title of host publicationAdvances in Clinical Chemistry
PublisherAcademic Press Inc.
DOIs
StatePublished - Apr 22 2024

Publication series

NameAdvances in Clinical Chemistry
ISSN (Print)0065-2423
ISSN (Electronic)2162-9471

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Clinical Biochemistry

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