Bilateral Iris Depigmentation and Ocular Hypotony as End-Stage Manifestations of Untreated Vogt-Koyanagi-Harada Disease.

Miguel Cuevas, Alejandra de-la-Torre, Andrea Córdoba

Research output: Contribution to journalArticle

Abstract

Purpose: To describe severe bilateral iris depigmentation and persistent ocular hypotony as end-stage manifestations of untreated Vogt–Koyanagi–Harada disease. Methods: We present the clinical findings and diagnostic studies performed for three patients with bilateral iris depigmentation. Results: Vogt–Koyanagi–Harada disease in late recurrent stage was diagnosed in three patients with bilateral severe iris depigmentation and persistent ocular hypotony. Conclusions: Early diagnosis and treatment of inflammation are crucial factors in the clinical outcome of Vogt–Koyanagi–Harada disease. When left undiagnosed and untreated from early stages, severe iris depigmentation and ocular hypotony, uncommon manifestations of this disease, can develop.

Original languageEnglish (US)
Article numberPMID: 28548582
Pages (from-to)1-6
Number of pages6
JournalOcular Immunology and Inflammation
Early online dateMar 26 2017
DOIs
StatePublished - May 26 2017

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Ocular Hypotension
Uveomeningoencephalitic Syndrome
Iris
Early Diagnosis
Inflammation

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Ophthalmology

Concepts

  • Concept
  • Iris atrophy
  • Iris depigmentations
  • VKH; Vogt–Koyanagi–Harada disease
  • ocular hypotony
  • panuveitis

Cite this

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title = "Bilateral Iris Depigmentation and Ocular Hypotony as End-Stage Manifestations of Untreated Vogt-Koyanagi-Harada Disease.",
abstract = "Purpose: To describe severe bilateral iris depigmentation and persistent ocular hypotony as end-stage manifestations of untreated Vogt–Koyanagi–Harada disease. Methods: We present the clinical findings and diagnostic studies performed for three patients with bilateral iris depigmentation. Results: Vogt–Koyanagi–Harada disease in late recurrent stage was diagnosed in three patients with bilateral severe iris depigmentation and persistent ocular hypotony. Conclusions: Early diagnosis and treatment of inflammation are crucial factors in the clinical outcome of Vogt–Koyanagi–Harada disease. When left undiagnosed and untreated from early stages, severe iris depigmentation and ocular hypotony, uncommon manifestations of this disease, can develop.",
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AU - Cuevas, Miguel

AU - de-la-Torre, Alejandra

AU - Córdoba, Andrea

PY - 2017/5/26

Y1 - 2017/5/26

N2 - Purpose: To describe severe bilateral iris depigmentation and persistent ocular hypotony as end-stage manifestations of untreated Vogt–Koyanagi–Harada disease. Methods: We present the clinical findings and diagnostic studies performed for three patients with bilateral iris depigmentation. Results: Vogt–Koyanagi–Harada disease in late recurrent stage was diagnosed in three patients with bilateral severe iris depigmentation and persistent ocular hypotony. Conclusions: Early diagnosis and treatment of inflammation are crucial factors in the clinical outcome of Vogt–Koyanagi–Harada disease. When left undiagnosed and untreated from early stages, severe iris depigmentation and ocular hypotony, uncommon manifestations of this disease, can develop.

AB - Purpose: To describe severe bilateral iris depigmentation and persistent ocular hypotony as end-stage manifestations of untreated Vogt–Koyanagi–Harada disease. Methods: We present the clinical findings and diagnostic studies performed for three patients with bilateral iris depigmentation. Results: Vogt–Koyanagi–Harada disease in late recurrent stage was diagnosed in three patients with bilateral severe iris depigmentation and persistent ocular hypotony. Conclusions: Early diagnosis and treatment of inflammation are crucial factors in the clinical outcome of Vogt–Koyanagi–Harada disease. When left undiagnosed and untreated from early stages, severe iris depigmentation and ocular hypotony, uncommon manifestations of this disease, can develop.

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JO - Ocular Immunology and Inflammation

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