TY - JOUR
T1 - Autonomic symptoms following Zika virus infection
AU - Rodríguez, Yhojan
AU - Rojas, Manuel
AU - Ramírez-Santana, Carolina
AU - Acosta-Ampudia, Yeny
AU - Monsalve, Diana M.
AU - Anaya, Juan Manuel
N1 - Funding Information:
Funding source This study was supported by Universidad del Rosario (ABN011), and Colciencias (747-2016), Bogotá, Colombia.
Publisher Copyright:
© 2018, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Purpose: To determine if autonomic symptoms are associated with previous Zika virus infection. Methods: Case–control study including 35 patients with Zika virus infection without evidence of neurological disease and 105 controls. Symptoms of autonomic dysfunction were assessed with the composite autonomic symptom scale 31 (COMPASS-31). Results: Patients with previous Zika virus infection had significantly higher COMPASS-31 score than controls regardless of age and sex (p = 0.007). The main drivers for the higher scores where orthostatic intolerance (p = 0.003), secretomotor (p = 0.04) and bladder symptoms (p < 0.001). Conclusion: Zika virus infection is associated with autonomic dysfunction. The mechanisms remain to be elucidated.
AB - Purpose: To determine if autonomic symptoms are associated with previous Zika virus infection. Methods: Case–control study including 35 patients with Zika virus infection without evidence of neurological disease and 105 controls. Symptoms of autonomic dysfunction were assessed with the composite autonomic symptom scale 31 (COMPASS-31). Results: Patients with previous Zika virus infection had significantly higher COMPASS-31 score than controls regardless of age and sex (p = 0.007). The main drivers for the higher scores where orthostatic intolerance (p = 0.003), secretomotor (p = 0.04) and bladder symptoms (p < 0.001). Conclusion: Zika virus infection is associated with autonomic dysfunction. The mechanisms remain to be elucidated.
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U2 - 10.1007/s10286-018-0515-1
DO - 10.1007/s10286-018-0515-1
M3 - Research Article
C2 - 29497887
AN - SCOPUS:85044196238
SN - 0959-9851
VL - 28
SP - 211
EP - 214
JO - Clinical Autonomic Research
JF - Clinical Autonomic Research
IS - 2
ER -