Autoimmunity in Guillain-Barré syndrome associated with Zika virus infection and beyond

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

Autoimmune diseases share common immunopathogenic mechanisms (i.e., the autoimmune tautology), which explain the clinical similarities among them as well as their familial clustering. Guillain-Barré syndrome (GBS), an autoimmune peripheral neuropathy, has been recently associated with Zika virus (ZIKV) infection. Based on a series of cases, this review article provides a comparative analysis of GBS associated with ZIKV infection, contrasted with the general characteristics of GBS in light of the autoimmune tautology, including gender differences in prevalence, subphenotypes, polyautoimmunity, familial autoimmunity, age at onset, pathophysiology, ecology, genetics, ancestry, and treatment.

Original languageEnglish (US)
Pages (from-to)327-334
Number of pages8
JournalAutoimmunity Reviews
Volume16
Issue number4
DOIs
StatePublished - Apr 1 2017

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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