Autoimmune hepatitis - learning about your patients from their autoantibody profiles.

Margaret Corrigan, Gideon M R Hirschfield, Ye H Oo, David H Adams, Collette Thain, Martine Walmsley, Ann Brownlee, David E J Dave Jones, Palak J Trivedi, Chris J Weston, Gwilym J Webb, Philip N Newsome, Gideon M R Hirschfield, David H Adams, Evaggelia Liaskou, Gideon M R Hirschfield, J E Eaton, Brian D Juran, Elizabeth J Atkinson, Erik M SchlichtX Xie, Maria Margarita Manrique Andrade, Craig S Lammert, Velimir A Luketic, Joseph A Odin, A A Koteish, Kris V Kowdley, K B Chopra, Gideon M R Hirschfield, N P Chalasani, Konstantinos N Lazaridis, Willem J Lammers, Henk R van Buuren, Gideon M R Hirschfield, Bettina E Hansen, Jessica K Dyson, Gideon M R Hirschfield, David H Adams, Ulrich Beuers, Derek A Mann, Keith D Lindor, David E J Dave Jones, Palak J Trivedi, Willem J Lammers, Henk R van Buuren, Albert Pares, Annarosa Floreani, Harry L A J Janssen, Pietro Invernizzi, Pier Maria Battezzati, Cyriel Y Ponsioen, Christophe Corpechot, Raoul Poupon, Marlyn J Mayo, Andrew K Burroughs, Frederik Nevens, Andrew L Mason, Kris V Kowdley, Ana Lleo, Llorenc Caballeria, Keith D Lindor, Bettina E Hansen, Gideon M R Hirschfield, Andrew L Mason, Velimir A Luketic, Keith D Lindor, Stuart C Gordon, Marlyn J Mayo, Kris V Kowdley, Catherine Vincent, Henry C Jr Bodhenheimer, Albert Pares, Michael Trauner, Hanns-Ulrich Marschall, Luciano Adorini, Cathi Sciacca, Tessa Beecher-Jones, Erin Castelloe, Olaf Bohm, David Shapiro, Laura M Stinton, Chelsea Bentow, Michael Mahler, Gary L Norman, Bertus Eksteen, Andrew L Mason, Gilaad G Kaplan, Bjorn Lindkvist, Gideon M R Hirschfield, Piotr Milkiewicz, Angela C Cheung, Harry L A J Janssen, Marvin J. Fritzler, Gwilym J Webb, Gideon M R Hirschfield, Gary L Norman, Chen Yen Yang, Heather P Ostendorff, Zakera Shums, Mark J Lim, Jinjun Wang, Amany Awad, Gideon M R Hirschfield, Piotr Milkiewicz, Donald B Bloch, Kenneth J Rothschild, Christopher L Bowlus, Iannis E Adamopoulos, Patrick S C Leung, Harry L A J Janssen, Angela C Cheung, Catalina Coltescu, M. Eric Gershwin, Jessica K Dyson, Gwilym J Webb, Gideon M R Hirschfield, Ansgar W Lohse, Ulrich Beuers, Keith D Lindor, David E J Dave Jones, Leah C. Kottyan, Erin Zoller, Jessica Bene, Xiaoming Lu, Jennifer A. Kelly, Andrew M. Rupert, Christopher J. Lessard, Samuel E. Vaughn, Miranda C. Marion, Matthew T. Weirauch, Bahram Namjou, Adam Adler, Astrid Rasmussen, Stuart B. Glenn, Courtney G. Montgomery, Gideon M R Hirschfield, Gang Xie, Catalina Coltescu, Christopher I. Amos, He Li, John A. Ice, Swapan K. Nath, Xavier Mariette, Simon Bowman, Maureen Rischmueller, Sue Lester, Johan G. Brun, Lasse G Goransson, Erna Harboe, Roald Omdal, Deborah S. Cunninghame-Graham, Tim Vyse, Corinne Miceli-Richard, Michael T. Brennan, James A. Lessard, Marie Wahren-Herlenius, Marika Kvarnstrom, Gabor G. Illei, Torsten Witte, Roland Jonsson, Per Eriksson, Gunnel Nordmark, Wan Fai Ng, Juan-Manuel Anaya, Nelson L. Rhodus, Barbara M. Segal, Joan T. Merrill, Judith A. James, Joel M. Guthridge, R. Hal Scofield, Marta E. Alarcon-Riquelme, Sang Cheol Bae, Susan A. Boackle, Lindsey A. Criswell, Gary S. Gilkeson, Diane L. Kamen, Chaim O. Jacob, Robert P. Kimberly, Elizabeth E. Brown, Jeffrey C. Edberg, Graciela S Alarcon, John D. Reveille, Luis M Vila, Michelle Petri, Rosalind Ramsey-Goldman, Barry I. Freedman, Timothy B. Niewold, Anne M. Stevens, Betty P. Tsao, Jun Ying, Maureen D. Mayes, Olga Y. Gorlova, Ward Wakeland, Timothy Radstake, Ezequiel Martin, Javier Martin, Katherine A. Siminovitch, Kathy L. Moser Sivils, Patrick M. Gaffney, Carl D. Langefeld, John B. Harley, Kenneth M. Kaufman, Willem J Lammers, Henk R van Buuren, Gideon M R Hirschfield, Harry L A J Janssen, Pietro Invernizzi, Andrew L Mason, Cyriel Y Ponsioen, Annarosa Floreani, Christophe Corpechot, Marlyn J Mayo, Pier Maria Battezzati, Albert Pares, Frederik Nevens, Andrew K Burroughs, Kris V Kowdley, Palak J Trivedi, Teru Kumagi, Angela C Cheung, Ana Lleo, Mohamad H Imam, Kirsten Boonstra, Nora Cazzagon, Irene Franceschet, Raoul Poupon, Llorenc Caballeria, Giulia Pieri, Pushpjeet S Kanwar, Keith D Lindor, Bettina E Hansen, Gwilym J Webb, Gideon M R Hirschfield, Palak J Trivedi, Tony Bruns, Ka-Kit Li, Gideon M R Hirschfield, Evaggelia Liaskou, Gideon M R Hirschfield, M. Eric Gershwin, Christophe Hezode, Gideon M R Hirschfield, Wayne Ghesquiere, William Sievert, Maribel Rodriguez-Torres, Stephen D Shafran, Paul J Thuluvath, Harvey A Tatum, Imam Waked, Gamal Esmat, Eric J Lawitz, Vinod K Rustgi, Stanislas Pol, Nina Weis, Paul J Pockros, Marc Bourliere, Lawrence Serfaty, John M Vierling, Michael W Fried, Ola Weiland, Maurizia R Brunetto, Gregory T Everson, Stefan Zeuzem, Paul Y Kwo, Mark Sulkowski, Norbert Brau, Dennis Hernandez, Fiona McPhee, Megan Wind-Rotolo, Zhaohui Liu, Stephanie Noviello, Eric A Hughes, Philip D Yin, Steven Schnittman, Tom Hemming Karlsen, Sandra E Fischer, Palak J Trivedi, Stephen Ward, Paul D Greig, George Therapondos, Gideon M R Hirschfield, Katherine A. Siminovitch, Evaggelia Liaskou, Louisa E Jeffery, Palak J Trivedi, Gary M Reynolds, Shankar Suresh, Tony Bruns, David H Adams, David M Sansom, Gideon M R Hirschfield, N Rajoriya, P Clift, S Thorne, Gideon M R Hirschfield, J W Ferguson, Peter Fickert, Marion J Pollheimer, Ulrich Beuers, Carolin Lackner, Gideon M R Hirschfield, Chantal Housset, Verena Keitel, Christoph Schramm, Hanns-Ulrich Marschall, Tom Hemming Karlsen, Espen Melum, Arthur Kaser, Bertus Eksteen, Mario Strazzabosco, Michael P Manns, Michael Trauner, Ajay Tokala, Korosh Khalili, Ravi Menezes, Gideon M R Hirschfield, Kartik S Jhaveri, Palak J Trivedi, Tony Bruns, Angela C Cheung, Ka-Kit Li, Clemens Kittler, Teru Kumagi, Hemant Husnain Shah, Christopher Corbett, Nadya Al-Harthy, Unsal Acarsu, Catalina Coltescu, Dhiraj Tripathi, Andreas Stallmach, James M Neuberger, Harry L A J Janssen, Gideon M R Hirschfield, Ewa Wunsch, Jocelyn Trottier, Malgorzata Milkiewicz, Joanna Raszeja-Wyszomirska, Gideon M R Hirschfield, Olivier Barbier, Piotr Milkiewicz, Gwilym J Webb, Ahmed M Elsharkawy, Gideon M R Hirschfield, Rachel E Dickinson, Paul Milne, Laura Jardine, Sasan Zandi, Sabina I Swierczek, Naomi McGovern, Sharon Cookson, Zaveyna Ferozepurwalla, Alexander Langridge, Sarah Pagan, Andrew Gennery, Tarja Heiskanen-Kosma, Sari Hamalainen, Mikko Seppanen, Matthew Helbert, Eleni Tholouli, Eleonora Gambineri, Sigrun Reykdal, Magnus Gottfreethsson, James E Thaventhiran, Emma Morris, Gideon M R Hirschfield, Alex G Richter, Stephen Jolles, Chris M Bacon, Sophie Hambleton, Muzlifah Haniffa, Yenan Bryceson, Carl Allen, Josef T Prchal, John E Dick, Venetia Bigley, Matthew Collin, Palak J Trivedi, Teru Kumagi, Nadya Al-Harthy, Catalina Coltescu, Stephen Ward, Angela C Cheung, Gideon M R Hirschfield, Harshna Patel, Korosh Khalili, Kim Tae Kyoung, Leyla Yazdi, Eric Lee, Gary May, Paul Kortan, Catalina Coltescu, Gideon M R Hirschfield, Stefan Zeuzem, Thomas Berg, Edward Gane, Peter Ferenci, Graham R Foster, Michael W Fried, Christophe Hezode, Gideon M R Hirschfield, Ira Jacobson, Igor Nikitin, Paul J Pockros, Fred Poordad, Jane James Scott, Oliver Lenz, Monika Peeters, Vanitha Sekar, Goedele De Smedt, Rekha Sinha, Maria Beumont-Mauviel, Tom Hemming Karlsen, Keith D Lindor, David H Adams, David F Schaeffer, Lay Lay Win, Sara Hafezi-Bakhtiari, Maria Cino, Gideon M R Hirschfield, Hala El-Zimaity, Palak J Trivedi, Gideon M R Hirschfield, Imran Patanwala, Peter McMeekin, Ruth Walters, George F Mells, Graeme J Alexander, Julia L Newton, Hemant Husnain Shah, Catalina Coltescu, Gideon M R Hirschfield, Mark Hudson, David E J Dave Jones, Jimmy Z Liu, Johannes Roksund Hov, Trine Folseraas, Eva Ellinghaus, Simon M Rushbrook, Nadezhda T Doncheva, Ole A Andreassen, Rinse K Weersma, Tobias J Weismuller, Bertus Eksteen, Pietro Invernizzi, Gideon M R Hirschfield, Daniel Nils Gotthardt, Albert Pares, David Ellinghaus, Tejas Shah, Brian D Juran, Piotr Milkiewicz, Christian Rust, Christoph Schramm, Tobias Muller, Brijesh Srivastava, Georgios George N Dalekos, Markus M Nothen, Stefan Herms, Juliane Winkelmann, Mitja Mitrovic, Felix Braun, Cyriel Y Ponsioen, Peter J P Croucher, Martina Sterneck, Andreas Teufel, Andrew L Mason, Janna Saarela, Virpi Leppa, Ruslan Dorfman, Domenico Alvaro, Annarosa Floreani, Suna Onengut-Gumuscu, Stephen S Rich, Wesley K Thompson, Andrew J Schork, Sigrid Naess, Ingo Thomsen, Gabriele Mayr, Inke R Konig, Kristian Hveem, Isabelle Cleynen, Javier Gutierrez-achury, Isis Ricano-Ponce, David van Heel, Einar Bjornsson, Richard N Sandford, Peter R Durie, Espen Melum, Morten H Vatn, Mark S Silverberg, Richard H Duerr, Leonid Padyukov, Stephan Brand, Miquel Sans, Vito Annese, Jean-Paul Achkar, Kirsten Muri Boberg, Hanns-Ulrich Marschall, Olivier Chazouilleres, Christopher L Bowlus, Cisca Wijmenga, Erik Schrumpf, Severine Vermeire, Mario Albrecht, John D Rioux, Graeme J Alexander, Annika Bergquist, Judy H. Cho, Stefan Schreiber, Michael P Manns, Martti Farkkila, Anders M Dale, Roger W Chapman, Konstantinos N Lazaridis, Andre Franke, Carl A Anderson, Tom Hemming Karlsen, Frank Lammert, Konstantinos N Lazaridis, Andrew L Mason, Greta Pells, George F Mells, Marco Carbone, Julia L Newton, Andrew J Bathgate, Andrew K Burroughs, Michael A Heneghan, James M Neuberger, Darren B Day, Samantha J Ducker, Richard N Sandford, Graeme J Alexander, David E J Dave Jones, Paraskevi A Vlachou, Errol Colak, Alexander Koculym, Anish Kirpalani, Tae Kyoung Kim, Gideon M R Hirschfield, Marie E Faughnan, S P Kar, Michael F Seldin, Wei Chen, E Lu, Gideon M R Hirschfield, Pietro Invernizzi, Jenny Heathcote, Daniele Cusi, M. Eric Gershwin, Katherine A. Siminovitch, Christopher I. Amos, Sanjeev Sockalingam, Diana Blank, Abdulqader Al Jarad, Fahad Alosaimi, Gideon M R Hirschfield, Susan E Abbey, Brian D Juran, Gideon M R Hirschfield, Pietro Invernizzi, Elizabeth J Atkinson, Yun Yafang Li, Gang Xie, Roman Kosoy, Michael Ransom, Ye Sun, Ilaria Bianchi, Erik M Schlicht, Ana Lleo, Catalina Coltescu, Francesca Bernuzzi, Mauro Podda, Craig S Lammert, Russell Shigeta, Landon L Chan, Tobias Balschun, Maurizio Marconi, Daniele Cusi, Elizabeth Jenny Heathcote, Andrew L Mason, Rebecca M Robert P Myers, Piotr Milkiewicz, Joseph A Odin, Velimir A Luketic, Bruce R Bacon, Henry C Jr Bodenheimer, Valentina Liakina, Catherine Vincent, Cynthia Levy, Andre Franke, Peter K Gregersen, Fabrizio Bossa, M. Eric Gershwin, Mariza deAndrade, Christopher I. Amos, Konstantinos N Lazaridis, Michael F Seldin, Katherine A. Siminovitch, Sanjeev Sockalingam, Diana Blank, Nour Abdelhamid, Susan E Abbey, Gideon M R Hirschfield, Palak J Trivedi, Gideon M R Hirschfield, A Moores, Susan Fox, Anthony Lang, Gideon M R Hirschfield, Natasha Chandok, Gideon M R Hirschfield, Amreen M Dinani, Sandra E Fischer, Jeffrey Mosko, Maha Guindi, Gideon M R Hirschfield, Gang Xie, E Lu, Ye Sun, Brian D Juran, V Chellappa, Catalina Coltescu, Andrew L Mason, Piotr Milkiewicz, Rebecca M Robert P Myers, Joseph A Odin, Velimir A Luketic, Bruce R Bacon, Henry C Jr Bodenheimer, Valentina Liakina, Catherine Vincent, Cynthia Levy, S Pillai, Konstantinos N Lazaridis, Christopher I. Amos, Katherine A. Siminovitch, Binita Maya Kamath, Robert C Bauer, Kathleen M Loomes, Grace Chao, Jennifer Gerfen, Anne Hutchinson, Winita Hardikar, Gideon M R Hirschfield, Paloma Jara, Ian D Krantz, Pablo Lapunzina, Laura Leonard, Simon Ling, Vicky Lee Ng, Phuc Le Hoang, David A Piccoli, Nancy Bettina Spinner, Darryl Huang, Elaheh Aghdassi, Jiandong Su, Jeffrey Mosko, Gideon M R Hirschfield, Dafna Gladman, Murray B Urowitz, Paul R. Fortin, Qinglong Jin, Yuki Moritoki, Ana Lleo, Koichi Tsuneyama, Pietro Invernizzi, Hitoshi Moritoki, Kentaro Kikuchi, Zhe-Xiong Lian, Gideon M R Hirschfield, Aftab Ansari, Ross L Coppel, M. Eric Gershwin, Junqi Niu, Teru Kumagi, Joost P H Drenth, Orlee Guttman, Vicky Lee Ng, Les Lilly, George Therapondos, Yoichi Hiasa, Kojiro Michitaka, Morikazu Onji, Yuji Watanabe, Sambit Sen, William J H Griffiths, Eve Roberts, Jenny Heathcote, Gideon M R Hirschfield, Khalid Alswat, Nadya Al-Harthy, Waseem Mazrani, Ghazi Alshumrani, Kartik S Jhaveri, Gideon M R Hirschfield, John C. Chambers, Weihua Zhang, Joban Sehmi, Xinzhong Li, Mark N Wass, Pim van der Harst, Hilma Holm, Serena Sanna, Maryam Kavousi, Sebastian E Baumeister, Lachlan J Coin, Guohong Deng, Christian Gieger, Nancy L Heard-Costa, Jouke-Jan Hottenga, Brigitte Kuhnel, Vinod Kumar, Vasiliki Lagou, Liming Liang, Jian'an Luan, Pedro Marques Vidal, Irene Mateo Leach, Paul F O'Reilly, John F Peden, Nilufer Rahmioglu, Pasi Soininen, Elizabeth K Speliotes, Xin Yuan, Gudmar Thorleifsson, Behrooz Z Alizadeh, Larry D Atwood, Ingrid B Borecki, Morris J Brown, Pimphen Charoen, Francesco Cucca, Debashish Das, Eco J C de Geus, Anna L Dixon, Angela Doring, Georg Ehret, Gudmundur I Eyjolfsson, Martin Farrall, Nita G Forouhi, Nele Friedrich, Wolfram Goessling, Daniel F Gudbjartsson, Tamara B. Harris, Anna-Liisa Hartikainen, Simon Heath, Gideon M R Hirschfield, Albert Hofman, Georg Homuth, Elina Hypponen, Harry L A J Janssen, Toby Johnson, Antti J Kangas, Ido P Kema, Jens P Kuhn, Sandra Lai, Mark Lathrop, Markus M Lerch, Yun Yafang Li, T Jake Liang, Jing-Ping Lin, Ruth J F Loos, Nicholas G Martin, Miriam F Moffatt, Grant W Montgomery, Patricia B. Munroe, Kiran Musunuru, Yusuke Nakamura, Christopher J O'Donnell, Isleifur Olafsson, Brenda W Penninx, Anneli Pouta, Bram P. Prins, Inga Prokopenko, Ralf Puls, Aimo Ruokonen, Markku J Savolainen, David Schlessinger, Jeoffrey N L Schouten, Udo Seedorf, Srijita Sen-Chowdhry, Katherine A. Siminovitch, Johannes H Smit, Timothy D. Spector, Wenting Tan, Tanya M Teslovich, Taru Tukiainen, Andre G André G Uitterlinden, Melanie van der Klauw, Ramachandran S Vasan, Chris Wallace, Henri Wallaschofski, H-Erich Wichmann, Gonneke Willemsen, Peter Wurtz, Chun Xu, Laura M Yerges-Armstrong, Goncalo R Abecasis, Kourosh R Ahmadi, Dorret I Boomsma, Mark Caulfield, William O Cookson, Cornelia M. van Duijn, Philippe Froguel, Koichi Matsuda, Mark I Mccarthy, Christa Meisinger, Vincent Mooser, Kirsi H Pietilainen, Gunter Schumann, Harold Snieder, Michael J E Sternberg, Ronald P. Stolk, Howard C Thomas, Unnur Thorsteinsdottir, Manuela Uda, Gerard Waeber, Nicholas J Wareham, Dawn M Waterworth, Hugh Watkins, John B Whitfield, Jacqueline C M Witteman, Bruce H R Wolffenbuttel, Caroline S Fox, Mika Ala-Korpela, Kari Stefansson, Peter Vollenweider, Henry Volzke, Eric E Schadt, Jane James Scott, Marjo-Riitta Jarvelin, Paul Elliott, Jaspal S. Kooner, Paraskevi A Vlachou, Korosh Khalili, Hyun-Jung Jang, Sandra E Fischer, Gideon M R Hirschfield, Tae Kyoung Kim, Sanjeev Sockalingam, Diana Blank, Abdulqader Al Jarad, Fahad Alosaimi, Gideon M R Hirschfield, Susan E Abbey, Pietro Invernizzi, M. Eric Gershwin, Kirsten Muri Boberg, Roger W Chapman, Gideon M R Hirschfield, Ansgar W Lohse, Michael P Manns, Erik Schrumpf, Haiying Liu, Gary L Norman, Zakera Shums, Howard J. Worman, Edward L Krawitt, Nicola Bizzaro, Diego Vergani, Dimitrios P. Bogdanos, Georgios George N Dalekos, Piotr Milkiewicz, Albert J Czaja, Elizabeth Jenny Heathcote, Gideon M R Hirschfield, Eng M Tan, Kiyomitsu Miyachi, Monica Bignotto, Pier Maria Battezzati, Ana Lleo, Patrick S C Leung, Mauro Podda, M. Eric Gershwin, Pietro Invernizzi, Elizabeth Jenny Heathcote, M. Eric Gershwin, Nadya Al-Harthy, Teru Kumagi, Catalina Coltescu, Gideon M R Hirschfield, Xiangdong Liu, Pietro Invernizzi, Yan Yue Lu, Roman Kosoy, Yan Yue Lu, Ilaria Bianchi, Mauro Podda, Chun Xu, Gang Xie, Fabio Macciardi, Carlo Selmi, Sara Lupoli, Russell Shigeta, Michael Ransom, Ana Lleo, Annette T Ah-Young Young Lee, Andrew L Mason, Rebecca M Robert P Myers, Kevork M Peltekian, Cameron N Ghent, Francesca Bernuzzi, Massimo Zuin, Floriano Rosina, Elisabetta Borghesio, Annarosa Floreani, Roberta Lazzari, Grazia Niro, Angelo Andriulli, Luigi Muratori, Paolo Muratori, Piero L Almasio, Pietro Andreone, Marzia Margotti, Maurizia R Brunetto, Barbara Coco, Domenico Alvaro, Maria C Bragazzi, Fabio Marra, Alessandro Pisano, Cristina Rigamonti, Massimo Colombo, Marco Marzioni, Antonio Benedetti, Luca Fabris, Mario Strazzabosco, Piero Portincasa, Vincenzo O Palmieri, Claudio Tiribelli, Lory Croce, Savino Bruno, Sonia Rossi, Maria Vinci, Cleofe Prisco, Alberto Mattalia, Pierluigi Toniutto, Antonio Picciotto, Andrea Galli, Carlo Ferrari, Silvia Colombo, Giovanni Casella, Lorenzo Morini, Nicola Caporaso, Agostino Colli, Giancarlo Spinzi, Renzo Montanari, Peter K Gregersen, Elizabeth Jenny Heathcote, Gideon M R Hirschfield, Katherine A. Siminovitch, Christopher I. Amos, M. Eric Gershwin, Michael F Seldin, Xiangdong Liu, Younghun Han, Ivan P Gorlov, Yan Yue Lu, Chun Xu, Yan Yue Lu, Wei Chen, Brian D Juran, Catalina Coltescu, Andrew L Mason, Piotr Milkiewicz, Rebecca M Robert P Myers, Joseph A Odin, Velimir A Luketic, Danute Speiciene, Catherine Vincent, Cynthia Levy, Peter K Gregersen, Jinyi Zhang, Elizabeth Jenny Heathcote, Konstantinos N Lazaridis, Christopher I. Amos, Katherine A. Siminovitch, Elizabeth J Atkinson, Joseph J Larson, Erik M Schlicht, Xiangdong Liu, Elizabeth Jenny Heathcote, Gideon M R Hirschfield, Katherine A. Siminovitch, Konstantinos N Lazaridis, Teru Kumagi, Maha Guindi, Sandra E Fischer, Tamara Arenovich, Rupert Abdalian, Catalina Coltescu, Elizabeth Jenny Heathcote, Gideon M R Hirschfield, Marilyn V Zeman, Gideon M R Hirschfield, Christopher I. Amos, Katherine A. Siminovitch, Kathryn L Nash, Gideon M R Hirschfield, Teru Kumagi, Yoichi Hiasa, Gideon M R Hirschfield, Katherine A. Siminovitch, Sofie Decock, Phyllis McGee, Gideon M R Hirschfield, Kathryn L Nash, Ian Bentley, Gideon M R Hirschfield, P Gibbs, William J H Griffiths, Xiangdong Liu, Chun Xu, Yan Yue Lu, Gang Xie, Yan Yue Lu, Xiangjun Gu, Erin J Walker, Kaiyan Jing, Brian D Juran, Andrew L Mason, Rebecca M Robert P Myers, Kevork M Peltekian, Cameron N Ghent, Catalina Coltescu, Elizabeth J Atkinson, Elizabeth Jenny Heathcote, Konstantinos N Lazaridis, Christopher I. Amos, Katherine A. Siminovitch, Erin J Walker, Gideon M R Hirschfield, Chun Xu, Yan Yue Lu, Xiangdong Liu, Yan Yue Lu, Catalina Coltescu, Kesheng Wang, William G Newman, Vivian P. Bykerk, Edward C. Keystone, Dianne Mosher, Christopher I. Amos, Elizabeth Jenny Heathcote, Katherine A. Siminovitch, Nadya Al-Harthi, Elizabeth Jenny Heathcote, M Bhat, Maha Guindi, Elizabeth Jenny Heathcote, Gideon M R Hirschfield, Teru Kumagi, Elizabeth Jenny Heathcote, Richard Dillon, Gideon M R Hirschfield, Michael E D Allison, Kanchan P Rege, Teru Kumagi, Khalid Alswat, Gideon M R Hirschfield, Jenny Heathcote, Elizabeth Jenny Heathcote, Jenny Heathcote, Glenys A Tennent, Winston L Hutchinson, Melvyn C Kahan, Gideon M R Hirschfield, J Ruth Jr Gallimore, Jackie Lewin, Caroline A Sabin, Amar P Dhillon, Mark B Pepys, Graeme J Alexander, Mark B Pepys, Gideon M R Hirschfield, Glenys A Tennent, J Ruth Jr Gallimore, Melvyn C Kahan, Vittorio Bellotti, Philip N Hawkins, Rebecca M Robert P Myers, Martin D Smith, Alessandra Polara, Alexander J A Cobb, Steven V Ley, J Andrew Aquilina, Carol V Robinson, Isam Sharif, Gillian A Gray, Caroline A Sabin, Michelle C Jenvey, Simon E Kolstoe, Darren Thompson, Stephen P Wood, Winston L Hutchinson, Caroline A Sabin, G Martin Benson, Amar P Dhillon, Glenys A Tennent, Mark B Pepys, Brian R Clapp, Gideon M R Hirschfield, Clare Storry, J Ruth Jr Gallimore, Ray P Stidwill, Mervyn Singer, John E Deanfield, Raymond J MacAllister, Mark B Pepys, Patrick Vallance, Aroon D Hingorani, A H Gomma, Gideon M R Hirschfield, J Ruth Jr Gallimore, Gordon D O Lowe, Mark B Pepys, K M Fox, John Danesh, Jeremy G Wheeler, Gideon M R Hirschfield, Shinichi Eda, Gudny Eiriksdottir, Ann Rumley, Gordon D O Lowe, Mark B Pepys, Vilmundur Gudnason, Jeff Herbert, Melvyn C Kahan, Mark B Pepys, Philip N Hawkins, Mark B Pepys, Gideon M R Hirschfield, Christopher P. Evans, Scot Smith, Gideon M R Hirschfield, E Rigopoulou, T G Wreghitt, D G Wight, C J Taylor, Graeme J Alexander, Mark B Pepys, Gideon M R Hirschfield, M McNeil, P J Brennan, P F Barnes, V Mehra, Gideon M R Hirschfield, S J Fong, C Abou-Zeid, G A Rook, S W Hunter, P J Brennan, R L Modlin, D L Drow, C H Baum, Gideon M R Hirschfield

Research output: Contribution to journalArticlepeer-review

253 Scopus citations

Abstract

Cholestatic liver disorders are caused by genetic defects, mechanical aberrations, toxins, or dysregulations in the immune system that damage the bile ducts and cause accumulation of bile and liver tissue damage. They have common clinical manifestations and pathogenic features that include the responses of cholangiocytes and hepatocytes to injury. We review the features of bile acid transport, tissue repair and regulation, apoptosis, vascular supply, immune regulation, and cholangiocytes that are associated with cholestatic liver disorders. We now have a greater understanding of the physiology of cholangiocytes at the cellular and molecular levels, as well as genetic factors, repair pathways, and autoimmunity mechanisms involved in the pathogenesis of disease. These discoveries will hopefully lead to new therapeutic approaches for patients with cholestatic liver disease.
Original languageEnglish (US)
Pages (from-to)1299-1304
Number of pages6
JournalJournal of Hepatology
Volume12
Issue number2
DOIs
StatePublished - Jun 7 2014

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