Aumento en la longevidad y reducción de la agregación de alfa sinucleína en la cepa NL5901 de Caenorhabditis elegans tratada con cannabidiol.

Translated title of the contribution: Increased longevity and reduced alpha-synuclein aggregation in cannabidiol-treated Caenorhabditis elegans strain NL5901.

Alejandra Mantilla Galindo, Karen Lorena Hidalgo Pulido, Rodrigo Esteban Gonzalez Reyes, Ruth Mélida Sánchez Mora

Research output: Contribution to conferencePosterpeer-review

Abstract

Cannabidiol (CBD), a phytocannabinoid from the Cannabis sativa plant, has potential neuroprotective properties. The use of the nematode Caenorhabditis elegans (C. elegans) is a preclinical in vivo model that allows screening of promising molecules for the treatment and study of neurodegenerative diseases such as Parkinson's disease (PD). Alpha synuclein is a protein involved in synaptic vesicle trafficking, which is altered and is part of Lewy bodies in PD. C. elegans strain NL5901 expresses human alpha-synuclein, which allows us to evaluate in vivo changes in this protein. To evaluate the effect of cannabidiol in C. elegans strain NL5901. Objectives: To determine the effect of cannabidiol on the longevity of the C. elegans strains included in the study. To describe the effect of cannabidiol on α-synuclein aggregates in the transgenic C. elegans strain. CBD treatment significantly increased longevity in strain NL5901 from 23 days (CI 0.1-1.1) for controls to 58 days (CI 0.8-7.5) for those receiving 0.3µM CBD. CBD at 3µM increased longevity to 40 days (CI 0.6-5.2), while CBD at 30µM increased it to 50 days (CI 0.8-5.8). Likewise, alpha synuclein aggregates were significantly decreased compared to the control group (mean IF 88.84 ± 38.46) vs 0.3 µM (IF 32.56 ± 12.25), vs 3 µM (IF 36.32 ± 11.36), vs 30 µM ( IF 24.89 ± 6.6). In conclusion, CBD treatment in NL5901 nematodes showed increased longevity and decreased alpha synuclein aggregation in vivo.
Translated title of the contributionIncreased longevity and reduced alpha-synuclein aggregation in cannabidiol-treated Caenorhabditis elegans strain NL5901.
Original languageSpanish (Colombia)
Pages1
Number of pages1
StateSubmitted - Nov 18 2022
Event20°vo Día de la Investigación. Fundación Cardio Infantil.: Dos décadas generando conocimiento. - Fundación Cardio Infantil, Bogotá, Colombia
Duration: Nov 17 2022Nov 18 2022
https://cardioinfantil.org/eventos/20-dia-de-la-investigacion/

Conference

Conference20°vo Día de la Investigación. Fundación Cardio Infantil.
Country/TerritoryColombia
CityBogotá
Period11/17/2211/18/22
Internet address

All Science Journal Classification (ASJC) codes

  • Neuroscience (miscellaneous)

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