TY - CHAP
T1 - Assessment of the myogenic and metabolic mechanism influence in cerebral autoregulation using near-infrared spectroscopy
AU - Caicedo, Alexander
AU - Naulaers, Gunnar
AU - Wolf, Martin
AU - Lemmers, Petra
AU - Van Bel, Frank
AU - Ameye, Lieveke
AU - Van Huffel, Sabine
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2012
Y1 - 2012
N2 - Cerebral autoregulation is normally controlled via three different mechanisms, namely: the myogenic, the metabolic, and the neurogenic one. The myogenic mechanism responds efficiently to slow changes in mean arterial blood pressure (MABP) while the metabolic one is more efficient with fast changes. The neurogenic mechanism is not yet well understood. As changes in cerebral intravascular oxygenation (HbD), measured with near-infrared spectroscopy (NIRS), reflect changes in cerebral blood flow, the myogenic influence in the cerebral autoregulation can be assessed by analysis of HbD and MABP; the metabolic influence can be assessed by analysis of the HbD and the partial pressure of carbon dioxide (pCO2). We performed a transfer function analysis in order to calculate the gain and phase of the HbD/MABP and HbD/PCO2 subsystems. Due to the fact that cerebral autoregulation may be absent in sick premature infants, we then investigated how well these parameters could predict clinical outcome in this population.
AB - Cerebral autoregulation is normally controlled via three different mechanisms, namely: the myogenic, the metabolic, and the neurogenic one. The myogenic mechanism responds efficiently to slow changes in mean arterial blood pressure (MABP) while the metabolic one is more efficient with fast changes. The neurogenic mechanism is not yet well understood. As changes in cerebral intravascular oxygenation (HbD), measured with near-infrared spectroscopy (NIRS), reflect changes in cerebral blood flow, the myogenic influence in the cerebral autoregulation can be assessed by analysis of HbD and MABP; the metabolic influence can be assessed by analysis of the HbD and the partial pressure of carbon dioxide (pCO2). We performed a transfer function analysis in order to calculate the gain and phase of the HbD/MABP and HbD/PCO2 subsystems. Due to the fact that cerebral autoregulation may be absent in sick premature infants, we then investigated how well these parameters could predict clinical outcome in this population.
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U2 - 10.1007/978-1-4614-1566-4_6
DO - 10.1007/978-1-4614-1566-4_6
M3 - Chapter
C2 - 22259079
AN - SCOPUS:84856286131
SN - 9781461415657
T3 - Advances in Experimental Medicine and Biology
SP - 37
EP - 44
BT - Oxygen Transport to Tissue XXXIII
ER -