TY - JOUR
T1 - Association between FTO (ns9939609) genotype and adiposity markers in Chilean adults
AU - Petermann, Fanny
AU - Villagrán, Marcelo
AU - Troncoso, Claudia
AU - Mardones, Lorena
AU - Leiva, Ana María
AU - Martínez, María Adela
AU - Garrido-Méndez, Alex
AU - Poblete-Valderrama, Felipe
AU - Salas-Bravo, Carlos
AU - Ramírez-Vélez, Robinson
AU - Ulloa, Natalia
AU - Pérez-Bravo, Francisco
AU - Celis-Morales, Carlos
N1 - Publisher Copyright:
© 2018, Sociedad Medica de Santiago. All rights reserved.
PY - 2018/6/1
Y1 - 2018/6/1
N2 - © 2018, Sociedad Medica de Santiago. All rights reserved. Background: Numerous studies have identified the role of Fat-mass-associated-gene (FTO) in the development of obesity. Aim: To investigate the association of FTO gene with adiposity markers in Chilean adults. Material and Methods: 409 participants were included in this cross-sectional study. The association between FTO (rs9939609) genotype and adiposity markers was determined using linear regression analyses. Adiposity markers included were: body weight, body mass index, fat mass, waist circumference, hip circumference and waist/hip ratio. Results: A fully adjusted model showed a significant association between FTO genotype and body weight (2.16 kg per each extra copy of the risk allele [95% confidence intervals (CI): 0.45 to 3.87], p = 0.014), body mass index (0.61 kg.m-2[95% CI: 0.12 to 1.20], p = 0.050) and fat mass (1.14% [95% CI: 0.39 to 1.89], p = 0.010). The greater magnitude of association was found between the FTO gene and fat mass when the outcomes were standardized to z-score. Conclusions: This study confirms an association between the FTO gene and adiposity markers in Chilean adults, which is independent of major confounding factors.
AB - © 2018, Sociedad Medica de Santiago. All rights reserved. Background: Numerous studies have identified the role of Fat-mass-associated-gene (FTO) in the development of obesity. Aim: To investigate the association of FTO gene with adiposity markers in Chilean adults. Material and Methods: 409 participants were included in this cross-sectional study. The association between FTO (rs9939609) genotype and adiposity markers was determined using linear regression analyses. Adiposity markers included were: body weight, body mass index, fat mass, waist circumference, hip circumference and waist/hip ratio. Results: A fully adjusted model showed a significant association between FTO genotype and body weight (2.16 kg per each extra copy of the risk allele [95% confidence intervals (CI): 0.45 to 3.87], p = 0.014), body mass index (0.61 kg.m-2[95% CI: 0.12 to 1.20], p = 0.050) and fat mass (1.14% [95% CI: 0.39 to 1.89], p = 0.010). The greater magnitude of association was found between the FTO gene and fat mass when the outcomes were standardized to z-score. Conclusions: This study confirms an association between the FTO gene and adiposity markers in Chilean adults, which is independent of major confounding factors.
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U2 - 10.4067/s0034-98872018000600717
DO - 10.4067/s0034-98872018000600717
M3 - Article
C2 - 30148903
AN - SCOPUS:85052338201
VL - 146
SP - 717
EP - 726
JO - Revista Medica de Chile
JF - Revista Medica de Chile
SN - 0034-9887
IS - 6
ER -