Association between FTO (ns9939609) genotype and adiposity markers in Chilean adults

Fanny Petermann, Marcelo Villagrán, Claudia Troncoso, Lorena Mardones, Ana María Leiva, María Adela Martínez, Alex Garrido-Méndez, Felipe Poblete-Valderrama, Carlos Salas-Bravo, Robinson Ramírez-Vélez, Natalia Ulloa, Francisco Pérez-Bravo, Carlos Celis-Morales

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

© 2018, Sociedad Medica de Santiago. All rights reserved. Background: Numerous studies have identified the role of Fat-mass-associated-gene (FTO) in the development of obesity. Aim: To investigate the association of FTO gene with adiposity markers in Chilean adults. Material and Methods: 409 participants were included in this cross-sectional study. The association between FTO (rs9939609) genotype and adiposity markers was determined using linear regression analyses. Adiposity markers included were: body weight, body mass index, fat mass, waist circumference, hip circumference and waist/hip ratio. Results: A fully adjusted model showed a significant association between FTO genotype and body weight (2.16 kg per each extra copy of the risk allele [95% confidence intervals (CI): 0.45 to 3.87], p = 0.014), body mass index (0.61 kg.m-2[95% CI: 0.12 to 1.20], p = 0.050) and fat mass (1.14% [95% CI: 0.39 to 1.89], p = 0.010). The greater magnitude of association was found between the FTO gene and fat mass when the outcomes were standardized to z-score. Conclusions: This study confirms an association between the FTO gene and adiposity markers in Chilean adults, which is independent of major confounding factors.
Translated title of the contributionAsociación entre el genotipo FTO (ns9939609) y los marcadores de adiposidad en adultos chilenos
Original languageEnglish (US)
Pages (from-to)717-726
Number of pages10
JournalRevista Medica de Chile
Volume146
Issue number6
DOIs
StatePublished - Jun 1 2018

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