Asociación de factores genéticos y no-genéticos con la severidad de la infección por sars-cov2 en población colombiana

Mariana Angulo-Aguado, Juan Camilo Carrillo, David Corredor Orlandelli, Mónica González, Ruth Eliana Pineda Mateus, Maria Carolina Rojas Polo, Paula Triana-Fonseca, Nora Constanza Contreras Bravo, Adrien Morel, Katherine Parra-Abaunza, Carlos Martin Restrepo Fernandez, Oscar Javier Ortega Recalde, Dora Janeth Fonseca Mendoza

Research output: Contribution to conferenceAbstractpeer-review

Abstract

Genetic and non-genetic factors are responsible for the high interindividual variability in the response to SARS-CoV-2. Although numerous genetic polymorphisms have been identified as risk factors for severe COVID-19, these remain understudied in LatinAmerican populations. This study evaluated the association of non-genetic factors and three polymorphisms: ACE rs4646994, ACE2 rs2285666, and LZTFL1 rs11385942, with COVID severity and long-term symptoms by using a case-control design. The control group was composed of asymptomatic/mild cases (n = 61) recruited from a private laboratory, while the case group was composed of severe/critical patients (n = 63) hospitalized in the Hospital Universitario Mayor-Méderi, both institutions located in Bogotá, Colombia. Clinical follow up and exhaustive revision of medical records allowed us to assess non-genetic factors. Genotypification of the polymorphism of interest was performed by amplicon size analysis and Sanger sequencing. In agreement with previous reports, we found a statistically significant association between age, male sex, and comorbidities, such as hypertension and type 2 diabetes mellitus (T2DM), and worst outcomes. We identified the polymorphism LZTFL1 rs11385942 as an important risk factor for hospitalization (p < 0.01; OR = 5.73; 95% CI = 1.2– 26.5, under the allelic test). Furthermore, long-term symptoms were common among the studied population and associated with disease severity. No association between the polymorphisms examined and long-term symptoms was found. Comparison of allelic frequencies with other populations revealed significant differences for the three polymorphisms investigated. Finally, we used the statistically significant genetic and non-genetic variables to develop a predictive logistic regression model, which was implemented in a Shiny web application. Model discrimination was assessed using the area under the receiver operating characteristic curve (AUC = 0.86; 95% confidence interval 0.79–0.93). These results suggest that LZTFL1 rs11385942 may be a potential biomarker for COVID-19 severity in addition to conventional non-genetic risk factors.
Original languageSpanish (Colombia)
Pages1-1
Number of pages1
StateSubmitted - Oct 29 2021
Event6to encuentro de investigacion CIMED - , Colombia
Duration: Oct 29 2021Oct 29 2021

Exhibition

Exhibition6to encuentro de investigacion CIMED
Country/TerritoryColombia
Period10/29/2110/29/21

All Science Journal Classification (ASJC) codes

  • Genetics

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