Antifungal susceptibility of clinical Cryptococcus gattii isolates from Colombia varies among molecular types

Carolina Firacative; Patricia Escandón

doi:10.1093/mmy/myab041

Antifungal susceptibility of clinical Cryptococcus gattii isolates from Colombia varies among molecular types

Carolina Firacative
, Patricia Escandón

Research output: Contribution to Journal › Research Article › peer-review

11 Scopus citations

Abstract

Cryptococcosis by Cryptococcus gattii is endemic in Colombia, affecting mostly immunocompetent hosts. Since antifungal susceptibility differs between molecular types of cryptococcal isolates, as reported elsewhere, the aim of this study was to determine if 42 Colombian clinical isolates, VGI, VGII and VGIII, differ in the susceptibility to commonly used antifungals, using Sensititre plates. Among the molecular types, six non-wild type isolates to fluconazole, voriconazole and 5-flucytosine, were identified. Besides, VGI and VGII were less susceptible to 5-flucytosine and azoles, respectively, than other molecular types. These findings support the applicability of practicing susceptibility testing, which could better guide treatment in cryptococcosis.

Translated title of the contribution	La susceptibilidad antifúngica de aislados clínicos de Cryptococcus gattii procedentes de Colombia varía según los tipos moleculares
Original language	English (US)
Pages (from-to)	1122
Number of pages	1125
Journal	Medical Mycology
Volume	59
Issue number	11
Early online date	Jul 15 2021
DOIs	https://doi.org/10.1093/mmy/myab041
State	Published - Nov 2021
Event	Congress on Trends in Medical Mycology - Aberdeen, United Kingdom Duration: Oct 8 2021 → Oct 11 2021 Conference number: 10th https://www.timm2021.org/

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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General Medicine

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@article{cff145883f0d4f0d855ebf80c22f89d0,

title = "Antifungal susceptibility of clinical Cryptococcus gattii isolates from Colombia varies among molecular types",

abstract = "Cryptococcosis by Cryptococcus gattii is endemic in Colombia, affecting mostly immunocompetent hosts. Since antifungal susceptibility differs between molecular types of cryptococcal isolates, as reported elsewhere, the aim of this study was to determine if 42 Colombian clinical isolates, VGI, VGII and VGIII, differ in the susceptibility to commonly used antifungals, using Sensititre plates. Among the molecular types, six non-wild type isolates to fluconazole, voriconazole and 5-flucytosine, were identified. Besides, VGI and VGII were less susceptible to 5-flucytosine and azoles, respectively, than other molecular types. These findings support the applicability of practicing susceptibility testing, which could better guide treatment in cryptococcosis.",

author = "Carolina Firacative and Patricia Escand{\'o}n",

note = "{\textcopyright} The Author(s) 2021. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology.; Congress on Trends in Medical Mycology, 10th TIMM ; Conference date: 08-10-2021 Through 11-10-2021",

year = "2021",

month = nov,

doi = "10.1093/mmy/myab041",

language = "English (US)",

volume = "59",

pages = "1122",

journal = "Medical Mycology",

issn = "1369-3786",

publisher = "Oxford University Press",

number = "11",

url = "https://www.timm2021.org/",

}

TY - JOUR

T1 - Antifungal susceptibility of clinical Cryptococcus gattii isolates from Colombia varies among molecular types

AU - Firacative, Carolina

AU - Escandón, Patricia

N1 - Conference code: 10th

PY - 2021/11

Y1 - 2021/11

N2 - Cryptococcosis by Cryptococcus gattii is endemic in Colombia, affecting mostly immunocompetent hosts. Since antifungal susceptibility differs between molecular types of cryptococcal isolates, as reported elsewhere, the aim of this study was to determine if 42 Colombian clinical isolates, VGI, VGII and VGIII, differ in the susceptibility to commonly used antifungals, using Sensititre plates. Among the molecular types, six non-wild type isolates to fluconazole, voriconazole and 5-flucytosine, were identified. Besides, VGI and VGII were less susceptible to 5-flucytosine and azoles, respectively, than other molecular types. These findings support the applicability of practicing susceptibility testing, which could better guide treatment in cryptococcosis.

AB - Cryptococcosis by Cryptococcus gattii is endemic in Colombia, affecting mostly immunocompetent hosts. Since antifungal susceptibility differs between molecular types of cryptococcal isolates, as reported elsewhere, the aim of this study was to determine if 42 Colombian clinical isolates, VGI, VGII and VGIII, differ in the susceptibility to commonly used antifungals, using Sensititre plates. Among the molecular types, six non-wild type isolates to fluconazole, voriconazole and 5-flucytosine, were identified. Besides, VGI and VGII were less susceptible to 5-flucytosine and azoles, respectively, than other molecular types. These findings support the applicability of practicing susceptibility testing, which could better guide treatment in cryptococcosis.

U2 - 10.1093/mmy/myab041

DO - 10.1093/mmy/myab041

M3 - Research Article

C2 - 34264298

SN - 1369-3786

VL - 59

SP - 1122

JO - Medical Mycology

JF - Medical Mycology

IS - 11

T2 - Congress on Trends in Medical Mycology

Y2 - 8 October 2021 through 11 October 2021

ER -

Antifungal susceptibility of clinical Cryptococcus gattii isolates from Colombia varies among molecular types

Abstract

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