Antifungal susceptibility of clinical Cryptococcus gattii isolates from Colombia varies among molecular types

Carolina Firacative, Patricia Escandón

Research output: Contribution to journalArticlepeer-review

Abstract

Cryptococcosis by Cryptococcus gattii is endemic in Colombia, affecting mostly immunocompetent hosts. Since antifungal susceptibility differs between molecular types of cryptococcal isolates, as reported elsewhere, the aim of this study was to determine if 42 Colombian clinical isolates, VGI, VGII and VGIII, differ in the susceptibility to commonly used antifungals, using Sensititre plates. Among the molecular types, six non-wild type isolates to fluconazole, voriconazole and 5-flucytosine, were identified. Besides, VGI and VGII were less susceptible to 5-flucytosine and azoles, respectively, than other molecular types. These findings support the applicability of practicing susceptibility testing, which could better guide treatment in cryptococcosis.

Original languageEnglish (US)
Pages (from-to)1122
Number of pages1125
JournalMedical Mycology
Volume59
Issue number11
Early online dateJul 15 2021
DOIs
StatePublished - Nov 2021
EventCongress on Trends in Medical Mycology - Aberdeen, United Kingdom
Duration: Oct 8 2021Oct 11 2021
Conference number: 10th
https://www.timm2021.org/

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