Anti-infectious antibodies and autoimmune-associated autoantibodies in patients with type i diabetes mellitus and their close family members

Ilan Krause; Juan Manuel Anaya; Abigail Fraser; Ori Barzilai; Maya Ram; Verónica Abad; Alvaro Arango; Jorge García; Yehuda Shoenfeld

doi:10.1111/j.1749-6632.2009.04619.x

Anti-infectious antibodies and autoimmune-associated autoantibodies in patients with type i diabetes mellitus and their close family members

Ilan Krause, Juan Manuel Anaya, Abigail Fraser, Ori Barzilai, Maya Ram, Verónica Abad, Alvaro Arango, Jorge García, Yehuda Shoenfeld

urosario

Research output: Chapter in Book/Inform › Conference contribution

48 Scopus citations

Abstract

Type 1 diabetes mellitus (T1DM) is an autoimmune disease with complex interactions between genetic and environmental factors. We compared antibody levels to various infectious agents and of autoimmune-associated autoantibodies between Colombian T1DM patients, their close family members and healthy controls. Significantly lower levels of antibodies against several infectious agents were detected in the T1DM patients. These included Helicobacter pylori (P = 0.01), cytomegalovirus (P = 0.001), Epstein-Barr virus (P = 0.02) and Toxoplasma (P = 0.001). T1DM patients had significantly higher levels of IgG-anti-gliadin antibodies (P = 0.001) and IgG-antitissue transglutaminase antibodies (P = 0.03), and a borderline association with anticentromere antibodies (P = 0.06). The lower level of antibodies against infectious agents in T1DM patients may be related to their younger ages, but may also point to a protective role of those infections in T1DM development in susceptible individuals. Our results confirm the association between T1DM and celiac disease. A possible association with anticentromere antibody needs further studies.

Original language	English (US)
Title of host publication	Contemporary Challenges in Autoimmunity
Publisher	Blackwell Publishing, Inc.
Pages	633-639
Number of pages	7
ISBN (Print)	9781573317627
DOIs	https://doi.org/10.1111/j.1749-6632.2009.04619.x
State	Published - Sep 2009

Publication series

Name	Annals of the New York Academy of Sciences
Volume	1173
ISSN (Print)	0077-8923
ISSN (Electronic)	1749-6632

All Science Journal Classification (ASJC) codes

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/j.1749-6632.2009.04619.x

Cite this

Krause, I., Anaya, J. M., Fraser, A., Barzilai, O., Ram, M., Abad, V., Arango, A., García, J., & Shoenfeld, Y. (2009). Anti-infectious antibodies and autoimmune-associated autoantibodies in patients with type i diabetes mellitus and their close family members. In Contemporary Challenges in Autoimmunity (pp. 633-639). (Annals of the New York Academy of Sciences; Vol. 1173). Blackwell Publishing, Inc.. https://doi.org/10.1111/j.1749-6632.2009.04619.x

@inproceedings{4ad6e830fddf48c7b5bde8d4c61a696b,

title = "Anti-infectious antibodies and autoimmune-associated autoantibodies in patients with type i diabetes mellitus and their close family members",

abstract = "Type 1 diabetes mellitus (T1DM) is an autoimmune disease with complex interactions between genetic and environmental factors. We compared antibody levels to various infectious agents and of autoimmune-associated autoantibodies between Colombian T1DM patients, their close family members and healthy controls. Significantly lower levels of antibodies against several infectious agents were detected in the T1DM patients. These included Helicobacter pylori (P = 0.01), cytomegalovirus (P = 0.001), Epstein-Barr virus (P = 0.02) and Toxoplasma (P = 0.001). T1DM patients had significantly higher levels of IgG-anti-gliadin antibodies (P = 0.001) and IgG-antitissue transglutaminase antibodies (P = 0.03), and a borderline association with anticentromere antibodies (P = 0.06). The lower level of antibodies against infectious agents in T1DM patients may be related to their younger ages, but may also point to a protective role of those infections in T1DM development in susceptible individuals. Our results confirm the association between T1DM and celiac disease. A possible association with anticentromere antibody needs further studies.",

author = "Ilan Krause and Anaya, {Juan Manuel} and Abigail Fraser and Ori Barzilai and Maya Ram and Ver{\'o}nica Abad and Alvaro Arango and Jorge Garc{\'i}a and Yehuda Shoenfeld",

year = "2009",

month = sep,

doi = "10.1111/j.1749-6632.2009.04619.x",

language = "English (US)",

isbn = "9781573317627",

series = "Annals of the New York Academy of Sciences",

publisher = "Blackwell Publishing, Inc.",

pages = "633--639",

booktitle = "Contemporary Challenges in Autoimmunity",

address = "United States",

}

Krause, I, Anaya, JM, Fraser, A, Barzilai, O, Ram, M, Abad, V, Arango, A, García, J & Shoenfeld, Y 2009, Anti-infectious antibodies and autoimmune-associated autoantibodies in patients with type i diabetes mellitus and their close family members. in Contemporary Challenges in Autoimmunity. Annals of the New York Academy of Sciences, vol. 1173, Blackwell Publishing, Inc., pp. 633-639. https://doi.org/10.1111/j.1749-6632.2009.04619.x

Anti-infectious antibodies and autoimmune-associated autoantibodies in patients with type i diabetes mellitus and their close family members. / Krause, Ilan; Anaya, Juan Manuel; Fraser, Abigail et al.
Contemporary Challenges in Autoimmunity. Blackwell Publishing, Inc., 2009. p. 633-639 (Annals of the New York Academy of Sciences; Vol. 1173).

Research output: Chapter in Book/Inform › Conference contribution

TY - GEN

T1 - Anti-infectious antibodies and autoimmune-associated autoantibodies in patients with type i diabetes mellitus and their close family members

AU - Krause, Ilan

AU - Anaya, Juan Manuel

AU - Fraser, Abigail

AU - Barzilai, Ori

AU - Ram, Maya

AU - Abad, Verónica

AU - Arango, Alvaro

AU - García, Jorge

AU - Shoenfeld, Yehuda

PY - 2009/9

Y1 - 2009/9

N2 - Type 1 diabetes mellitus (T1DM) is an autoimmune disease with complex interactions between genetic and environmental factors. We compared antibody levels to various infectious agents and of autoimmune-associated autoantibodies between Colombian T1DM patients, their close family members and healthy controls. Significantly lower levels of antibodies against several infectious agents were detected in the T1DM patients. These included Helicobacter pylori (P = 0.01), cytomegalovirus (P = 0.001), Epstein-Barr virus (P = 0.02) and Toxoplasma (P = 0.001). T1DM patients had significantly higher levels of IgG-anti-gliadin antibodies (P = 0.001) and IgG-antitissue transglutaminase antibodies (P = 0.03), and a borderline association with anticentromere antibodies (P = 0.06). The lower level of antibodies against infectious agents in T1DM patients may be related to their younger ages, but may also point to a protective role of those infections in T1DM development in susceptible individuals. Our results confirm the association between T1DM and celiac disease. A possible association with anticentromere antibody needs further studies.

AB - Type 1 diabetes mellitus (T1DM) is an autoimmune disease with complex interactions between genetic and environmental factors. We compared antibody levels to various infectious agents and of autoimmune-associated autoantibodies between Colombian T1DM patients, their close family members and healthy controls. Significantly lower levels of antibodies against several infectious agents were detected in the T1DM patients. These included Helicobacter pylori (P = 0.01), cytomegalovirus (P = 0.001), Epstein-Barr virus (P = 0.02) and Toxoplasma (P = 0.001). T1DM patients had significantly higher levels of IgG-anti-gliadin antibodies (P = 0.001) and IgG-antitissue transglutaminase antibodies (P = 0.03), and a borderline association with anticentromere antibodies (P = 0.06). The lower level of antibodies against infectious agents in T1DM patients may be related to their younger ages, but may also point to a protective role of those infections in T1DM development in susceptible individuals. Our results confirm the association between T1DM and celiac disease. A possible association with anticentromere antibody needs further studies.

UR - http://www.scopus.com/inward/record.url?scp=69949184384&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69949184384&partnerID=8YFLogxK

U2 - 10.1111/j.1749-6632.2009.04619.x

DO - 10.1111/j.1749-6632.2009.04619.x

M3 - Conference contribution

C2 - 19758209

AN - SCOPUS:69949184384

SN - 9781573317627

T3 - Annals of the New York Academy of Sciences

SP - 633

EP - 639

BT - Contemporary Challenges in Autoimmunity

PB - Blackwell Publishing, Inc.

ER -

Krause I, Anaya JM, Fraser A, Barzilai O, Ram M, Abad V et al. Anti-infectious antibodies and autoimmune-associated autoantibodies in patients with type i diabetes mellitus and their close family members. In Contemporary Challenges in Autoimmunity. Blackwell Publishing, Inc. 2009. p. 633-639. (Annals of the New York Academy of Sciences). doi: 10.1111/j.1749-6632.2009.04619.x

Anti-infectious antibodies and autoimmune-associated autoantibodies in patients with type i diabetes mellitus and their close family members

Abstract

Publication series

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this