TY - JOUR
T1 - Analyzing biological and molecular characteristics and genomic damage induced by exposure to asbestos
AU - Ospina, Diana
AU - Villegas, Victoria Eugenia
AU - Rodríguez-Leguizamón, Giovanni
AU - Rondón-Lagos, Milena
N1 - Funding Information:
Graphic designer Elizabeth Cruz Tapias is acknowledged for the illustrations. The authors also thank MDPI English editing group for editing a draft of this manuscript. This research was funded by Corporación Hospitalaria Juan Ciudad – Hospital Universitario Mayor – Méderi.
Publisher Copyright:
© 2019 Zhang et al.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019
Y1 - 2019
N2 - Asbestos is one of the most important occupational carcinogens. Currently, about 125 million people worldwide are exposed to asbestos in the workplace. According to global estimates, at least 107,000 people die each year from lung cancer, mesothelioma, and asbestosis as a result of occupational exposure to asbestos. The high pathogenicity of this material is currently known, being associated with the development of pulmonary diseases, of which lung cancer is the main cause of death due to exposure to this mineral. Pulmonary diseases related to asbestos are a common clinical problem and a major health concern worldwide. Extensive research has identified many important pathogenic mechanisms; however, the precise molecular mechanisms involved, and the generated genomic damage that lead to the development of these diseases, are not completely understood. The modes of action that underlie this type of disease seem to differ depending on the type of fiber, lung clearance, and genetics. This evidences the need to increase our knowledge about these effects on human health. This review focuses on the characteristics of asbestos and the cellular and genomic damage generated in humans via exposure.
AB - Asbestos is one of the most important occupational carcinogens. Currently, about 125 million people worldwide are exposed to asbestos in the workplace. According to global estimates, at least 107,000 people die each year from lung cancer, mesothelioma, and asbestosis as a result of occupational exposure to asbestos. The high pathogenicity of this material is currently known, being associated with the development of pulmonary diseases, of which lung cancer is the main cause of death due to exposure to this mineral. Pulmonary diseases related to asbestos are a common clinical problem and a major health concern worldwide. Extensive research has identified many important pathogenic mechanisms; however, the precise molecular mechanisms involved, and the generated genomic damage that lead to the development of these diseases, are not completely understood. The modes of action that underlie this type of disease seem to differ depending on the type of fiber, lung clearance, and genetics. This evidences the need to increase our knowledge about these effects on human health. This review focuses on the characteristics of asbestos and the cellular and genomic damage generated in humans via exposure.
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U2 - 10.2147/CMAR.S205723
DO - 10.2147/CMAR.S205723
M3 - Review article
AN - SCOPUS:85067957322
SN - 1179-1322
VL - 11
SP - 4997
EP - 5012
JO - Cancer Management and Research
JF - Cancer Management and Research
ER -