TY - JOUR
T1 - An Unusual Renal Mass in Adolescent – Case Report and Literature Review
AU - Santafé Galvis, Jhonatan Sair
AU - Cruz Arévalo, Dilma Alexandra
AU - Salgado Tovar, Javier Mauricio
N1 - Funding Information:
En ese orden de ideas, el uso de marcadores inmunohistoquímicos resulta de notable ayuda y se convierten en valiosas herramientas para lograr un diagnóstico acertado. Existe la descripción inmunohistoquímica realizada para diferenciar un AM de un CCR tipo papilar y del TW de predominio epitelial,11,66 adaptada y configurada en el presente documento como aporte para el estudio de esa entidad (►Tabla 1. Marcadores en inmunohistoquímica descritos en TW, CCR y AM). Kinney y col., realizó un estudio con 37 AM (posteriormente reclasificados como pCCR), 13 pCCR y 20 TW donde plantea un patrón esperado para el AM así: CK7 negativo, AMACR negativo, WT1 positivo y CD57 positivo,12 asimismo plantean el FISH (Inmunohibridización in situ) como adyuvante para evaluar características que permiten descartar patologías como pCCR cuando exista evidencia alteraciones citogenéticas como ganancia o trisomía en cromosomas 7 y 17
Publisher Copyright:
© 2019 Sociedad Colombiana de Urología.
PY - 2019
Y1 - 2019
N2 - Introduction Renal neoplasms in pediatrics and adolescents patients are rare entities, 6–7% masses in pediatrics. In teenagers, set a noteworthy clinical challenge. Can manifest as variable signs or be asymptomatic. In scientific papers, Renal Cell Carcinoma and Wilms' tumor have been identified as the most prevalent tumors in aged lesser than 20 years; Metanephric Adenoma is an unusual pathologic entity into this population.Case Report A female youngster case, with left flank pain and monosymptomatic macroscopic hematuria, imaging studies show up a neoplastic appearance lesion at left kidney, demonstrated as Metanephric Adenoma afterwards by immunohistochemistry analysis. Literature review is performed by searching in the last three decades. Patient was taken to left radical nephrectomy, later the pathological analysis suggests Metanephric Adenoma, and with immunohistochemistry markers is supported this finding.Conclusions Renal masses in adolescents are uncommon. It is needed high clinical suspicion, a thorough physical examination and imaging techniques aid. Conventionally, histopathology determine diagnosis, although in some cases when doubt last, it is necessary perform immunohistochemistry. Renal Cell Carcinoma is the most prevalent in youth's renal masses, but there are indistinguishable conditions on imaging that raise a defiant clinical scenario; it is the purpose to provide a clinical guidance tool in the approach of Metanephric adenoma and contribute to the development of knowledge in a scarcely documented clinicopathological entity that doubtlessly will reverberate in best clinical practice and echo at science, social and economics.
AB - Introduction Renal neoplasms in pediatrics and adolescents patients are rare entities, 6–7% masses in pediatrics. In teenagers, set a noteworthy clinical challenge. Can manifest as variable signs or be asymptomatic. In scientific papers, Renal Cell Carcinoma and Wilms' tumor have been identified as the most prevalent tumors in aged lesser than 20 years; Metanephric Adenoma is an unusual pathologic entity into this population.Case Report A female youngster case, with left flank pain and monosymptomatic macroscopic hematuria, imaging studies show up a neoplastic appearance lesion at left kidney, demonstrated as Metanephric Adenoma afterwards by immunohistochemistry analysis. Literature review is performed by searching in the last three decades. Patient was taken to left radical nephrectomy, later the pathological analysis suggests Metanephric Adenoma, and with immunohistochemistry markers is supported this finding.Conclusions Renal masses in adolescents are uncommon. It is needed high clinical suspicion, a thorough physical examination and imaging techniques aid. Conventionally, histopathology determine diagnosis, although in some cases when doubt last, it is necessary perform immunohistochemistry. Renal Cell Carcinoma is the most prevalent in youth's renal masses, but there are indistinguishable conditions on imaging that raise a defiant clinical scenario; it is the purpose to provide a clinical guidance tool in the approach of Metanephric adenoma and contribute to the development of knowledge in a scarcely documented clinicopathological entity that doubtlessly will reverberate in best clinical practice and echo at science, social and economics.
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U2 - 10.1055/s-0038-1641726
DO - 10.1055/s-0038-1641726
M3 - Artículo de revisión
AN - SCOPUS:85077015325
SN - 0120-789X
VL - 28
SP - 321
EP - 329
JO - Urologia Colombiana
JF - Urologia Colombiana
IS - 4
ER -