Análisis farmacogenómico mediante secuenciación de siguiente generación (NGS) para la estimación de la implicación poligénica en la reactividad plaquetaria en pacientes tratados con clopidogrel

Translated title of the contribution: Pharmacogenomic analysis by next generation sequencing (NGS) for estimation of polygenic involvement in platelet reactivity in patients treated with clopidogrel

Omar Echeverría Gómez, Mariana Angulo Aguado, Cristian Gaviria, Nattaly Valero, Carlos Alberto Calderon Ospina, Katherine Parra, Nora Constanza Contreras Bravo, Adrien Morel, Carlos Martin Restrepo Fernandez, Oscar Javier Ortega Recalde, Luisa Fernanda Murcia Soriano, Dora Janeth Fonseca Mendoza

Research output: Contribution to conferencePosterpeer-review

Abstract

Against this background, the aim of the present study is to evaluate the polygenic impact on platelet reactivity in patients treated with clopidogrel in a group of patients with ACS treated at Méderi. The central hypothesis of this project is that it is possible to identify genetic risk factors in a population with a heterogeneous and unique gene pool such as our population. The proposed work will be the first comprehensive approach to study the impact of polymorphisms in various genes associated with the response to clopidogrel. We propose to perform this approach using a robust platform such as next-generation sequencing, population genetic analysis, and the construction of a polygenic risk score using multiple SNP analysis related to therapeutic response. Relevantly, this study may identify novel phenotype-related variants that can be proposed after functional validation as novel alleles and incorporated into worldwide databases such as CYP The Human Cytochrome P450 Allele Nomeclature (http://www.cypalleles.ki.se/).
Translated title of the contributionPharmacogenomic analysis by next generation sequencing (NGS) for estimation of polygenic involvement in platelet reactivity in patients treated with clopidogrel
Original languageSpanish (Colombia)
Pages1-1
Number of pages1
StateSubmitted - Sep 12 2023
EventV congreso Latinoamericano de Farmacogenomica y Medicina Personalizada

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Duration: Sep 6 2023Sep 12 2023

Seminar

SeminarV congreso Latinoamericano de Farmacogenomica y Medicina Personalizada

Period9/6/239/12/23

All Science Journal Classification (ASJC) codes

  • Genetics

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