A new framework for the assessment of cerebral hemodynamics regulation in neonates using nirs

Alexander Caicedo, Thomas Alderliesten, Gunnar Naulaers, Petra Lemmers, Frank Van Bel, Sabine Van Huffel

Research output: Chapter in Book/Report/Conference proceedingConference contribution

12 Scopus citations

Abstract

We present a new framework for the assessment of cerebral hemodynamics regulation (CHR) in neonates using near-infrared spectroscopy (NIRS). In premature infants, NIRS measurements have been used as surrogate variables for cerebral blood flow (CBF) in the assessment of cerebral autoregulation (CA). However, NIRS measurements only reflect changes in CBF under constant changes in arterial oxygen saturation (SaO2). This condition is unlikely to be met at the bedside in the NICU. Additionally, CA is just one of the different highly coupled mechanisms that regulate brain hemodynamics. Traditional methods for the assessment of CA do not take into account the multivariate nature of CHR, producing inconclusive results. In this study we propose a newly developed multivariate methodology for the assessment of CHR. This method is able to effectively decouple the influences of SaO2 from the NIRS measurements, and at the same time, produces scores indicating the strength of the coupling between the systemic variables and NIRS recordings. We explore the use of this method, and its derived scores, for the monitoring of CHR using data from premature infants who developed a grade III-IV intra-ventricular hemorrhage during the first 3 days of life.

Original languageEnglish (US)
Title of host publicationOxygen Transport to Tissue XXXVII
EditorsClare E. Elwell, Terence S. Leung, David K. Harrison
PublisherSpringer New York LLC
Pages501-509
Number of pages9
ISBN (Print)9781493930227
DOIs
StatePublished - 2016
Externally publishedYes
Event42nd Annual Meeting of International Society on Oxygen Transport to Tissue - London, United Kingdom
Duration: Jun 28 2014Jul 3 2014

Publication series

NameAdvances in Experimental Medicine and Biology
Volume876
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Conference

Conference42nd Annual Meeting of International Society on Oxygen Transport to Tissue
CountryUnited Kingdom
CityLondon
Period6/28/147/3/14

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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