A Naturally Occurring Antibody Fragment Neutralizes Infectivity of Diverse Infectious Agents

Luciano Polonelli, Tecla Ciociola, Lisa Elviri, Pier Paolo Zanello, Laura Giovati, Denise C. Arruda, Julián E. Muñoz, Renato A. Mortara, Giulia Morace, Elisa Borghi, Serena Galati, Oriano Marin, Claudio Casoli, Elisabetta Pilotti, Paola Ronzi, Luiz R. Travassos, Walter Magliani, Stefania Conti

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

A phosphorylated peptide, named K40H, derived from the constant region of IgMs was detected in human serum by liquid chromatography coupled to high-resolution mass spectrometry. Synthetic K40H proved to exert a potent in vitro activity against fungal pathogens, and to inhibit HIV-1 replication in vitro and ex vivo. It also showed a therapeutic effect against an experimental infection by Candida albicans in the invertebrate model Galleria mellonella. K40H represents the proof of concept of the innate role that naturally occurring antibody fragments may exert against infectious agents, shedding a new light upon the posthumous role of antibodies and opening a new scenario on the multifaceted functionality of humoral immunity.

Original languageEnglish (US)
Article number35018
JournalScientific Reports
Volume6
DOIs
StatePublished - Oct 11 2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

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