A mathematical model of the process of ligament repair: Effect of cold therapy and mechanical stress

Rosy Paola Cárdenas Sandoval, Diego Alexander Garzón-Alvarado, Angélica Maria Ramírez Martínez

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

This article proposes a mathematical model that predicts the wound healing process of the ligament after a sprain, grade II. The model describes the swelling, expression of the platelet-derived growth factor (PDGF), formation and migration of fibroblasts into the injury area and the expression of collagen fibers. Additionally, the model can predict the effect of ice treatment in reducing inflammation and the action of mechanical stress in the process of remodeling of collagen fibers. The results obtained from computer simulation show a high concordance with the clinical data previously reported by other authors.

Original languageEnglish (US)
Pages (from-to)53-61
Number of pages9
JournalJournal of Theoretical Biology
Volume302
DOIs
StatePublished - Jun 7 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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