A latitudinal gradient study of common anti-infectious agent antibody prevalence in Italy and Colombia

Victor Pordeus, Ori Barzilai, Yaniv Sherer, Ronir Raggio Luiz, Miri Blank, Nicola Bizzaro, Danilo Villalta, Juan Manuel Anaya, Yehuda Shoenfeld

Research output: Contribution to journalArticle

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Abstract

Background: Infectious agents are important in the pathogenesis of autoimmune disease since they are a major part of the environmental trigger of autoimmunity. A negative relationship between latitude and infectious disease species richness has been suggested. Objectives: To examine whether their prevalence differs in two latitudinally different populations. Methods: The prevalence of infections with Toxoplasma gondii, rubella virus, cytomegalovirus, Epstein-Barr virus and Treponema pallidum was compared between subjects from Italy and Colombia. Results: We found high titers of antibodies against four of five microorganisms tested, Toxoplasma gondii (50.8%), rubella virus (German measles) (75%), cytomegalovirus (86.3%), Epstein-Barr virus (83.3%) and Treponema pallidum (6.3%) in completely healthy individuals from a tropical country (Colombia) and a European country (Italy). Differences between two groups of volunteers were noted regarding two infectious agents. The prevalence of immunoglobulin G anti-rubella antibodies was significantly higher among Italian subjects (85% vs. 67.9%, P = 0.002), whereas antibodies against CMV were less prevalent among Italian as compared to Colombian subjects (77% vs. 92.9%, P <0.001). Conclusions: These differences might also result in a different tendency towards development of autoimmune diseases associated with these infectious agents in different populations.
Original languageEnglish (US)
Pages (from-to)65-68
Number of pages4
JournalIsrael Medical Association Journal
StatePublished - Jan 1 2008

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Colombia
Italy
Rubella virus
Treponema pallidum
Cytomegalovirus
Human Herpesvirus 4
Autoimmune Diseases
Antibodies
Rubella
Toxoplasmosis
Toxoplasma
Autoimmunity
Population
Communicable Diseases
Volunteers
Anti-Idiotypic Antibodies
Immunoglobulin G

Cite this

Pordeus, V., Barzilai, O., Sherer, Y., Luiz, R. R., Blank, M., Bizzaro, N., ... Shoenfeld, Y. (2008). A latitudinal gradient study of common anti-infectious agent antibody prevalence in Italy and Colombia. Israel Medical Association Journal, 65-68.
Pordeus, Victor ; Barzilai, Ori ; Sherer, Yaniv ; Luiz, Ronir Raggio ; Blank, Miri ; Bizzaro, Nicola ; Villalta, Danilo ; Anaya, Juan Manuel ; Shoenfeld, Yehuda. / A latitudinal gradient study of common anti-infectious agent antibody prevalence in Italy and Colombia. In: Israel Medical Association Journal. 2008 ; pp. 65-68.
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abstract = "Background: Infectious agents are important in the pathogenesis of autoimmune disease since they are a major part of the environmental trigger of autoimmunity. A negative relationship between latitude and infectious disease species richness has been suggested. Objectives: To examine whether their prevalence differs in two latitudinally different populations. Methods: The prevalence of infections with Toxoplasma gondii, rubella virus, cytomegalovirus, Epstein-Barr virus and Treponema pallidum was compared between subjects from Italy and Colombia. Results: We found high titers of antibodies against four of five microorganisms tested, Toxoplasma gondii (50.8{\%}), rubella virus (German measles) (75{\%}), cytomegalovirus (86.3{\%}), Epstein-Barr virus (83.3{\%}) and Treponema pallidum (6.3{\%}) in completely healthy individuals from a tropical country (Colombia) and a European country (Italy). Differences between two groups of volunteers were noted regarding two infectious agents. The prevalence of immunoglobulin G anti-rubella antibodies was significantly higher among Italian subjects (85{\%} vs. 67.9{\%}, P = 0.002), whereas antibodies against CMV were less prevalent among Italian as compared to Colombian subjects (77{\%} vs. 92.9{\%}, P <0.001). Conclusions: These differences might also result in a different tendency towards development of autoimmune diseases associated with these infectious agents in different populations.",
author = "Victor Pordeus and Ori Barzilai and Yaniv Sherer and Luiz, {Ronir Raggio} and Miri Blank and Nicola Bizzaro and Danilo Villalta and Anaya, {Juan Manuel} and Yehuda Shoenfeld",
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Pordeus, V, Barzilai, O, Sherer, Y, Luiz, RR, Blank, M, Bizzaro, N, Villalta, D, Anaya, JM & Shoenfeld, Y 2008, 'A latitudinal gradient study of common anti-infectious agent antibody prevalence in Italy and Colombia', Israel Medical Association Journal, pp. 65-68.

A latitudinal gradient study of common anti-infectious agent antibody prevalence in Italy and Colombia. / Pordeus, Victor; Barzilai, Ori; Sherer, Yaniv; Luiz, Ronir Raggio; Blank, Miri; Bizzaro, Nicola; Villalta, Danilo; Anaya, Juan Manuel; Shoenfeld, Yehuda.

In: Israel Medical Association Journal, 01.01.2008, p. 65-68.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A latitudinal gradient study of common anti-infectious agent antibody prevalence in Italy and Colombia

AU - Pordeus, Victor

AU - Barzilai, Ori

AU - Sherer, Yaniv

AU - Luiz, Ronir Raggio

AU - Blank, Miri

AU - Bizzaro, Nicola

AU - Villalta, Danilo

AU - Anaya, Juan Manuel

AU - Shoenfeld, Yehuda

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Background: Infectious agents are important in the pathogenesis of autoimmune disease since they are a major part of the environmental trigger of autoimmunity. A negative relationship between latitude and infectious disease species richness has been suggested. Objectives: To examine whether their prevalence differs in two latitudinally different populations. Methods: The prevalence of infections with Toxoplasma gondii, rubella virus, cytomegalovirus, Epstein-Barr virus and Treponema pallidum was compared between subjects from Italy and Colombia. Results: We found high titers of antibodies against four of five microorganisms tested, Toxoplasma gondii (50.8%), rubella virus (German measles) (75%), cytomegalovirus (86.3%), Epstein-Barr virus (83.3%) and Treponema pallidum (6.3%) in completely healthy individuals from a tropical country (Colombia) and a European country (Italy). Differences between two groups of volunteers were noted regarding two infectious agents. The prevalence of immunoglobulin G anti-rubella antibodies was significantly higher among Italian subjects (85% vs. 67.9%, P = 0.002), whereas antibodies against CMV were less prevalent among Italian as compared to Colombian subjects (77% vs. 92.9%, P <0.001). Conclusions: These differences might also result in a different tendency towards development of autoimmune diseases associated with these infectious agents in different populations.

AB - Background: Infectious agents are important in the pathogenesis of autoimmune disease since they are a major part of the environmental trigger of autoimmunity. A negative relationship between latitude and infectious disease species richness has been suggested. Objectives: To examine whether their prevalence differs in two latitudinally different populations. Methods: The prevalence of infections with Toxoplasma gondii, rubella virus, cytomegalovirus, Epstein-Barr virus and Treponema pallidum was compared between subjects from Italy and Colombia. Results: We found high titers of antibodies against four of five microorganisms tested, Toxoplasma gondii (50.8%), rubella virus (German measles) (75%), cytomegalovirus (86.3%), Epstein-Barr virus (83.3%) and Treponema pallidum (6.3%) in completely healthy individuals from a tropical country (Colombia) and a European country (Italy). Differences between two groups of volunteers were noted regarding two infectious agents. The prevalence of immunoglobulin G anti-rubella antibodies was significantly higher among Italian subjects (85% vs. 67.9%, P = 0.002), whereas antibodies against CMV were less prevalent among Italian as compared to Colombian subjects (77% vs. 92.9%, P <0.001). Conclusions: These differences might also result in a different tendency towards development of autoimmune diseases associated with these infectious agents in different populations.

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