A histoplasma capsulatum-specific IgG1 isotype monoclonal antibody, H1C, to a 70-kilodalton cell surface protein is not protective in murine histoplasmosis

Livia Cristina Liporagi Lopes; Allan J. Guimarães; Mariana Duarte De Cerqueira; Beatriz L. Gómez; Joshua D. Nosanchuk

doi:10.1128/CVI.00033-10

A histoplasma capsulatum-specific IgG1 isotype monoclonal antibody, H1C, to a 70-kilodalton cell surface protein is not protective in murine histoplasmosis

Livia Cristina Liporagi Lopes, Allan J. Guimarães, Mariana Duarte De Cerqueira, Beatriz L. Gómez, Joshua D. Nosanchuk

Research output: Contribution to journal › Research Article › peer-review

17 Scopus citations

Abstract

Monoclonal antibodies to Histoplasma capsulatum can modify pathogenesis. We now show that monoclonal antibody H1C to a 70-kDa antigen increases intracellular fungal growth and reduces macrophage nitric oxide release but has no effect on fungal burden or survival in murine infection. This further demonstrates the complexities of host-pathogen interactions.

Original language	English (US)
Pages (from-to)	1155-1158
Number of pages	4
Journal	Clinical and Vaccine Immunology
Volume	17
Issue number	7
DOIs	https://doi.org/10.1128/CVI.00033-10
State	Published - Jul 2010
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Clinical Biochemistry
Microbiology (medical)

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10.1128/CVI.00033-10

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title = "A histoplasma capsulatum-specific IgG1 isotype monoclonal antibody, H1C, to a 70-kilodalton cell surface protein is not protective in murine histoplasmosis",

abstract = "Monoclonal antibodies to Histoplasma capsulatum can modify pathogenesis. We now show that monoclonal antibody H1C to a 70-kDa antigen increases intracellular fungal growth and reduces macrophage nitric oxide release but has no effect on fungal burden or survival in murine infection. This further demonstrates the complexities of host-pathogen interactions.",

author = "Lopes, \{Livia Cristina Liporagi\} and Guimar{\~a}es, \{Allan J.\} and \{De Cerqueira\}, \{Mariana Duarte\} and G{\'o}mez, \{Beatriz L.\} and Nosanchuk, \{Joshua D.\}",

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A histoplasma capsulatum-specific IgG1 isotype monoclonal antibody, H1C, to a 70-kilodalton cell surface protein is not protective in murine histoplasmosis. / Lopes, Livia Cristina Liporagi; Guimarães, Allan J.; De Cerqueira, Mariana Duarte et al.
In: Clinical and Vaccine Immunology, Vol. 17, No. 7, 07.2010, p. 1155-1158.

Research output: Contribution to journal › Research Article › peer-review

TY - JOUR

T1 - A histoplasma capsulatum-specific IgG1 isotype monoclonal antibody, H1C, to a 70-kilodalton cell surface protein is not protective in murine histoplasmosis

AU - Lopes, Livia Cristina Liporagi

AU - Guimarães, Allan J.

AU - De Cerqueira, Mariana Duarte

AU - Gómez, Beatriz L.

AU - Nosanchuk, Joshua D.

PY - 2010/7

Y1 - 2010/7

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AB - Monoclonal antibodies to Histoplasma capsulatum can modify pathogenesis. We now show that monoclonal antibody H1C to a 70-kDa antigen increases intracellular fungal growth and reduces macrophage nitric oxide release but has no effect on fungal burden or survival in murine infection. This further demonstrates the complexities of host-pathogen interactions.

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DO - 10.1128/CVI.00033-10

M3 - Research Article

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AN - SCOPUS:77954382075

SN - 1556-6811

VL - 17

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ER -

A histoplasma capsulatum-specific IgG1 isotype monoclonal antibody, H1C, to a 70-kilodalton cell surface protein is not protective in murine histoplasmosis

Abstract

All Science Journal Classification (ASJC) codes

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