A functional variant in MIR137, a candidate gene for schizophrenia, affects Stroop test performance in young adults

Yeimy González-Giraldo; Rodrigo E. González-Reyes; Diego A. Forero

doi:10.1016/j.psychres.2016.01.006

A functional variant in MIR137, a candidate gene for schizophrenia, affects Stroop test performance in young adults

Yeimy González-Giraldo, Rodrigo E. González-Reyes, Diego A. Forero

Research output: Contribution to journal › Research Article › peer-review

12 Scopus citations

Abstract

MIR137, a brain expressed miRNA, has been identified as a top novel susceptibility gene for schizophrenia (SZ). 230 healthy participants completed the Stroop test and were genotyped for a functional Variable Number Tandem Repeat (VNTR) in MIR137 gene. MIR137 VNTR genotypes were associated with differences in Stroop facilitation and accuracies in congruent trials and for the total number of errors. This is the first study of the functional VNTR in MIR137 gene and Stroop test performance in healthy subjects. Our results could have important implications for the identification of genetic candidates for endophenotypes for SZ.

Original language	English (US)
Pages (from-to)	202-205
Number of pages	4
Journal	Psychiatry Research
Volume	236
DOIs	https://doi.org/10.1016/j.psychres.2016.01.006
State	Published - Feb 28 2016
Externally published	Yes

All Science Journal Classification (ASJC) codes

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.psychres.2016.01.006

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title = "A functional variant in MIR137, a candidate gene for schizophrenia, affects Stroop test performance in young adults",

abstract = "MIR137, a brain expressed miRNA, has been identified as a top novel susceptibility gene for schizophrenia (SZ). 230 healthy participants completed the Stroop test and were genotyped for a functional Variable Number Tandem Repeat (VNTR) in MIR137 gene. MIR137 VNTR genotypes were associated with differences in Stroop facilitation and accuracies in congruent trials and for the total number of errors. This is the first study of the functional VNTR in MIR137 gene and Stroop test performance in healthy subjects. Our results could have important implications for the identification of genetic candidates for endophenotypes for SZ.",

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AU - González-Giraldo, Yeimy

AU - González-Reyes, Rodrigo E.

AU - Forero, Diego A.

PY - 2016/2/28

Y1 - 2016/2/28

N2 - MIR137, a brain expressed miRNA, has been identified as a top novel susceptibility gene for schizophrenia (SZ). 230 healthy participants completed the Stroop test and were genotyped for a functional Variable Number Tandem Repeat (VNTR) in MIR137 gene. MIR137 VNTR genotypes were associated with differences in Stroop facilitation and accuracies in congruent trials and for the total number of errors. This is the first study of the functional VNTR in MIR137 gene and Stroop test performance in healthy subjects. Our results could have important implications for the identification of genetic candidates for endophenotypes for SZ.

AB - MIR137, a brain expressed miRNA, has been identified as a top novel susceptibility gene for schizophrenia (SZ). 230 healthy participants completed the Stroop test and were genotyped for a functional Variable Number Tandem Repeat (VNTR) in MIR137 gene. MIR137 VNTR genotypes were associated with differences in Stroop facilitation and accuracies in congruent trials and for the total number of errors. This is the first study of the functional VNTR in MIR137 gene and Stroop test performance in healthy subjects. Our results could have important implications for the identification of genetic candidates for endophenotypes for SZ.

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A functional variant in MIR137, a candidate gene for schizophrenia, affects Stroop test performance in young adults

Abstract

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