A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus

S. Wang, I. Adrianto, G. B. Wiley, C. J. Lessard, J. A. Kelly, A. J. Adler, S. B. Glenn, A. H. Williams, J. T. Ziegler, M. E. Comeau, M. C. Marion, B. E. Wakeland, C. Liang, K. M. Kaufman, J. M. Guthridge, M. E. Alarcón-Riquelme, G. S. Alarcón, J. M. Anaya, S. C. Bae, J. H. KimY. B. Joo, S. A. Boackle, E. E. Brown, M. A. Petri, R. Ramsey-Goldman, J. D. Reveille, L. M. Vilá, L. A. Criswell, J. C. Edberg, B. I. Freedman, G. S. Gilkeson, C. O. Jacob, J. A. James, D. L. Kamen, R. P. Kimberly, J. Martin, J. T. Merrill, T. B. Niewold, B. A. Pons-Estel, R. H. Scofield, A. M. Stevens, B. P. Tsao, T. J. Vyse, C. D. Langefeld, J. B. Harley, E. K. Wakeland, K. L. Moser, C. G. Montgomery, P. M. Gaffney

Research output: Contribution to journalArticle

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Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical manifestations characterized by the development of pathogenic autoantibodies manifesting in inflammation of target organs such as the kidneys, skin and joints. Genome-wide association studies have identified genetic variants in the UBE2L3 region that are associated with SLE in subjects of European and Asian ancestry. UBE2L3 encodes an ubiquitin-conjugating enzyme, UBCH7, involved in cell proliferation and immune function. In this study, we sought to further characterize the genetic association in the region of UBE2L3 and use molecular methods to determine the functional effect of the risk haplotype. We identified significant associations between variants in the region of UBE2L3 and SLE in individuals of European and Asian ancestry that exceeded a Bonferroni-corrected threshold (P
Original languageEnglish (US)
Pages (from-to)380-387
Number of pages8
JournalGenes and Immunity
DOIs
StatePublished - Jul 1 2012

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Systemic Lupus Erythematosus
Haplotypes
Ubiquitin-Conjugating Enzymes
Genome-Wide Association Study
Autoantibodies
Autoimmune Diseases
Joints
Cell Proliferation
Inflammation
Kidney
Skin

Cite this

Wang, S., Adrianto, I., Wiley, G. B., Lessard, C. J., Kelly, J. A., Adler, A. J., ... Gaffney, P. M. (2012). A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus. Genes and Immunity, 380-387. https://doi.org/10.1038/gene.2012.6
Wang, S. ; Adrianto, I. ; Wiley, G. B. ; Lessard, C. J. ; Kelly, J. A. ; Adler, A. J. ; Glenn, S. B. ; Williams, A. H. ; Ziegler, J. T. ; Comeau, M. E. ; Marion, M. C. ; Wakeland, B. E. ; Liang, C. ; Kaufman, K. M. ; Guthridge, J. M. ; Alarcón-Riquelme, M. E. ; Alarcón, G. S. ; Anaya, J. M. ; Bae, S. C. ; Kim, J. H. ; Joo, Y. B. ; Boackle, S. A. ; Brown, E. E. ; Petri, M. A. ; Ramsey-Goldman, R. ; Reveille, J. D. ; Vilá, L. M. ; Criswell, L. A. ; Edberg, J. C. ; Freedman, B. I. ; Gilkeson, G. S. ; Jacob, C. O. ; James, J. A. ; Kamen, D. L. ; Kimberly, R. P. ; Martin, J. ; Merrill, J. T. ; Niewold, T. B. ; Pons-Estel, B. A. ; Scofield, R. H. ; Stevens, A. M. ; Tsao, B. P. ; Vyse, T. J. ; Langefeld, C. D. ; Harley, J. B. ; Wakeland, E. K. ; Moser, K. L. ; Montgomery, C. G. ; Gaffney, P. M. / A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus. In: Genes and Immunity. 2012 ; pp. 380-387.
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abstract = "Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical manifestations characterized by the development of pathogenic autoantibodies manifesting in inflammation of target organs such as the kidneys, skin and joints. Genome-wide association studies have identified genetic variants in the UBE2L3 region that are associated with SLE in subjects of European and Asian ancestry. UBE2L3 encodes an ubiquitin-conjugating enzyme, UBCH7, involved in cell proliferation and immune function. In this study, we sought to further characterize the genetic association in the region of UBE2L3 and use molecular methods to determine the functional effect of the risk haplotype. We identified significant associations between variants in the region of UBE2L3 and SLE in individuals of European and Asian ancestry that exceeded a Bonferroni-corrected threshold (P",
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Wang, S, Adrianto, I, Wiley, GB, Lessard, CJ, Kelly, JA, Adler, AJ, Glenn, SB, Williams, AH, Ziegler, JT, Comeau, ME, Marion, MC, Wakeland, BE, Liang, C, Kaufman, KM, Guthridge, JM, Alarcón-Riquelme, ME, Alarcón, GS, Anaya, JM, Bae, SC, Kim, JH, Joo, YB, Boackle, SA, Brown, EE, Petri, MA, Ramsey-Goldman, R, Reveille, JD, Vilá, LM, Criswell, LA, Edberg, JC, Freedman, BI, Gilkeson, GS, Jacob, CO, James, JA, Kamen, DL, Kimberly, RP, Martin, J, Merrill, JT, Niewold, TB, Pons-Estel, BA, Scofield, RH, Stevens, AM, Tsao, BP, Vyse, TJ, Langefeld, CD, Harley, JB, Wakeland, EK, Moser, KL, Montgomery, CG & Gaffney, PM 2012, 'A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus', Genes and Immunity, pp. 380-387. https://doi.org/10.1038/gene.2012.6

A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus. / Wang, S.; Adrianto, I.; Wiley, G. B.; Lessard, C. J.; Kelly, J. A.; Adler, A. J.; Glenn, S. B.; Williams, A. H.; Ziegler, J. T.; Comeau, M. E.; Marion, M. C.; Wakeland, B. E.; Liang, C.; Kaufman, K. M.; Guthridge, J. M.; Alarcón-Riquelme, M. E.; Alarcón, G. S.; Anaya, J. M.; Bae, S. C.; Kim, J. H.; Joo, Y. B.; Boackle, S. A.; Brown, E. E.; Petri, M. A.; Ramsey-Goldman, R.; Reveille, J. D.; Vilá, L. M.; Criswell, L. A.; Edberg, J. C.; Freedman, B. I.; Gilkeson, G. S.; Jacob, C. O.; James, J. A.; Kamen, D. L.; Kimberly, R. P.; Martin, J.; Merrill, J. T.; Niewold, T. B.; Pons-Estel, B. A.; Scofield, R. H.; Stevens, A. M.; Tsao, B. P.; Vyse, T. J.; Langefeld, C. D.; Harley, J. B.; Wakeland, E. K.; Moser, K. L.; Montgomery, C. G.; Gaffney, P. M.

In: Genes and Immunity, 01.07.2012, p. 380-387.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus

AU - Wang, S.

AU - Adrianto, I.

AU - Wiley, G. B.

AU - Lessard, C. J.

AU - Kelly, J. A.

AU - Adler, A. J.

AU - Glenn, S. B.

AU - Williams, A. H.

AU - Ziegler, J. T.

AU - Comeau, M. E.

AU - Marion, M. C.

AU - Wakeland, B. E.

AU - Liang, C.

AU - Kaufman, K. M.

AU - Guthridge, J. M.

AU - Alarcón-Riquelme, M. E.

AU - Alarcón, G. S.

AU - Anaya, J. M.

AU - Bae, S. C.

AU - Kim, J. H.

AU - Joo, Y. B.

AU - Boackle, S. A.

AU - Brown, E. E.

AU - Petri, M. A.

AU - Ramsey-Goldman, R.

AU - Reveille, J. D.

AU - Vilá, L. M.

AU - Criswell, L. A.

AU - Edberg, J. C.

AU - Freedman, B. I.

AU - Gilkeson, G. S.

AU - Jacob, C. O.

AU - James, J. A.

AU - Kamen, D. L.

AU - Kimberly, R. P.

AU - Martin, J.

AU - Merrill, J. T.

AU - Niewold, T. B.

AU - Pons-Estel, B. A.

AU - Scofield, R. H.

AU - Stevens, A. M.

AU - Tsao, B. P.

AU - Vyse, T. J.

AU - Langefeld, C. D.

AU - Harley, J. B.

AU - Wakeland, E. K.

AU - Moser, K. L.

AU - Montgomery, C. G.

AU - Gaffney, P. M.

PY - 2012/7/1

Y1 - 2012/7/1

N2 - Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical manifestations characterized by the development of pathogenic autoantibodies manifesting in inflammation of target organs such as the kidneys, skin and joints. Genome-wide association studies have identified genetic variants in the UBE2L3 region that are associated with SLE in subjects of European and Asian ancestry. UBE2L3 encodes an ubiquitin-conjugating enzyme, UBCH7, involved in cell proliferation and immune function. In this study, we sought to further characterize the genetic association in the region of UBE2L3 and use molecular methods to determine the functional effect of the risk haplotype. We identified significant associations between variants in the region of UBE2L3 and SLE in individuals of European and Asian ancestry that exceeded a Bonferroni-corrected threshold (P

AB - Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical manifestations characterized by the development of pathogenic autoantibodies manifesting in inflammation of target organs such as the kidneys, skin and joints. Genome-wide association studies have identified genetic variants in the UBE2L3 region that are associated with SLE in subjects of European and Asian ancestry. UBE2L3 encodes an ubiquitin-conjugating enzyme, UBCH7, involved in cell proliferation and immune function. In this study, we sought to further characterize the genetic association in the region of UBE2L3 and use molecular methods to determine the functional effect of the risk haplotype. We identified significant associations between variants in the region of UBE2L3 and SLE in individuals of European and Asian ancestry that exceeded a Bonferroni-corrected threshold (P

U2 - 10.1038/gene.2012.6

DO - 10.1038/gene.2012.6

M3 - Article

C2 - 22476155

SP - 380

EP - 387

JO - Genes and Immunity

JF - Genes and Immunity

SN - 1466-4879

ER -

Wang S, Adrianto I, Wiley GB, Lessard CJ, Kelly JA, Adler AJ et al. A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus. Genes and Immunity. 2012 Jul 1;380-387. https://doi.org/10.1038/gene.2012.6