A compact view of isochores in the draft human genome sequence

Adam Pavlíček, Jan Pačes, Oliver Clay, Giorgio Bernardi

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


Prior to genome sequencing, information on base composition (GC level) and its variation in mammalian genomes could be obtained using density gradient ultracentrifugation. Analyses using this approach led to the conclusion that mammalian genomes are organized into mosaics of fairly homogeneous regions, called isochores. We present an initial compositional overview of the chromosomes of the recently available draft human genome sequence, in the form of color-coded moving window plots and corresponding GC level histograms. Results obtained from the draft human genome sequence agree well with those obtained or deduced earlier from CsCl experiments. The draft sequence now permits the visualization of the mosaic organization of the human genome at the DNA sequence level.

Original languageEnglish (US)
Pages (from-to)165-169
Number of pages5
JournalFEBS Letters
Issue number1-3
StatePublished - Jan 30 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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