18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Hao Wei Su, Javier L. Prieto, Lidan Wu, Han Wei Hou, Miguel Pinilla Vera, Diana Amador-Munoz, Joshua L. Englert, Bruce D. Levy, Rebecca M. Baron, Jongyoon Han, Joel Voldman

Research output: Contribution to conferencePaper

1 Scopus citations

Abstract

© 14CBMS.Sepsis represents the systemic inflammatory response caused by microbial infection in blood. Given the complexity of its pathophysiology, current extracorporeal blood purifications are based on non-selective removal of inflammatory mediators which have had limited success and feasibility in clinical settings. In this work, we developed a microfluidic blood purification approach for non-specific removal of bacteria and inflammatory cellular components (platelets and leukocytes) from whole blood using cell margination. We performed continuous blood filtration in vivo in mice and demonstrated long term modulation of host inflammatory response in a murine model of polymicrobial sepsis induced by cecal ligation and puncture (CLP).
Original languageEnglish (US)
Pages327-329
Number of pages3
StatePublished - Jan 1 2014
Externally publishedYes
Eventconference -
Duration: Jan 1 2014 → …

Conference

Conferenceconference
Period1/1/14 → …

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