Type I ROP16 regulates retinal inflammatory responses during ocular toxoplasmosis

Project: Research Project

Project Details


Ocular toxoplasmosis (OT), primarily retinochorioditis, is an important feature of infection with the protozoan parasite Toxoplasma gondii. The pathophysiology of this infection is still largely elusive; Especially the mouse models are not yet well developed. In contrast, numerous in vitro studies have shown the highly strain-dependent nature of Toxoplasma host-parasite interactions. A few distinct olimorphic virulence factors were characterized, in particular the rhoptry protein ROP16. Here, we study stress-dependent pathophysiology in our OT mouse.

Commitments / Obligations

Our animal study, including bilateral injection, was approved by the local ethics committee (project no.AL/77/84/02/13).
Effective start/end date6/12/191/8/20

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 4 - Quality Education

Main Funding Source

  • Competitive Funds


  • Europe


Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.