Study of the polymorphism of codon 72 of p53, as a risk of breast cancer in a Colombian population

The aim of this study is to investigate the association between the TP53 codon 72 polymorphism (rs1042522) and breast cancer susceptibility in a Colombian population. A case–control study will be conducted to determine the allelic and genotypic frequencies of the polymorphism and to evaluate its association with breast cancer risk and clinicopathological variables, including age at diagnosis, molecular subtype, histological grade, tumor stage, and treatment response. Genotyping will be performed using molecular biology techniques and DNA sequencing, followed by statistical analyses of genetic association. The findings are expected to clarify the role of the TP53 Arg72Pro polymorphism as a potential genetic susceptibility biomarker and to improve the understanding of genetic factors contributing to breast cancer development in the Colombian population.