Social cognition and processing in individuals with neurofibromatosis type 1: A systematic review

Neurofibromatosis type 1 is a genetic disease of autosomal dominant inheritance, relatively common (1:3,000 live births) and very heterogeneous, with autosomal dominant inheritance.
relatively common (1:3,000 live births) and very heterogeneous, with autosomal dominant inheritance, complete penetrance dominant, with complete penetrance and a highly variable expression with mainly neurological and cutaneous manifestations.
In addition to the typical clinical manifestations of this condition, NF1 patients have a heterogeneous cognitive profile. Up to 80 % of children with NF1 may have some form of cognitive
impairment, where the greatest difficulties are found in the processing of visuospatial information.
visuospatial information processing. In addition, the spectrum includes learning disabilities, behavioral problems, impaired executive function, reduced working memory and language disorders.
A high prevalence (53.8%) of Attention Deficit Hyperactivity Disorder (ADHD) has also been reported.
Attention Deficit Hyperactivity Disorder (ADHD). In addition, patients with NF1 may present with
Autism Spectrum Disorder (ASD) features.
This has led to the understanding that these patients have alterations in their social functioning, that they have tendencies to isolate social functioning, tendencies to isolate themselves, difficulties in initiating and maintaining friendships, deficits in emotion recognition, low concern for
recognition of emotions, low concern for others, among others.
However, little has been studied on possible alterations that these patients may present in relation to the domains of social cognition. C. S (e.g., empathy, theory of mind, social emotional
and moral judgment). Considering the above, it is evident the gap in the literature that exists about the CS in patients with NF1, so it is of utmost importance to address this issue in order to be able to design new coping strategies for the to be able to design new coping strategies and reduce the discomfort it causes in these patients.