Production and evaluation of the antifungal capacity of Satanin 1 immobilized in metallic nanoparticles against yeasts of the genus Candida.

Project: Research Project

Project Details


In the world, fungal infections caused by opportunistic yeasts represent important public health problems due to the high morbidity and mortality they present.

The frequency of candidemia varies depending on the hospitalization services and the risk factors, in addition to the incidence and resistance to antifungals that the yeasts present.

In Colombia, fungal infections caused by yeast species of the genus Candida are very common in hospitalized patients, with signs of immunosuppression and/or other comorbidities.

It is estimated that, in 2013, the frequency of invasive candidiasis presented higher data in Colombia compared to developed countries, increasing the incidence and prevalence by 2.3 cases per 1000 days of stay in intensive care units, which correspond to a 44% of isolations carried out.

Antimicrobial peptides have been studied in order to develop new therapeutic alternatives, especially against multidrug-resistant microorganisms, demonstrating effective sensitivity against different bacteria.

In addition, interdisciplinary techniques involving biomedical sciences and engineering are currently being developed with the purpose of advancing the treatment of different infectious diseases.

Among these techniques is the application of metallic nanoparticles for the treatment of infectious diseases, as an alternative therapy against pathogens, managing to design systems on the nanometric scale capable of acting as vehicles, largely mitigating the side effects produced by the drugs used in infection control.

Taking into account the above, it is proposed to design an immobilization system for the antimicrobial peptide Satanil 1 from the Dynastes satanás beetle, immobilized in metal nanoparticles, thanks to the compatibility they present, a controlled and prolonged release of the therapeutic compound can be ensured, to subsequently determine the anti-fungal activity of this conjugate against yeasts of clinical importance such as species of the genus Candida.


Antimicrobial peptides, Satanil 1, Candida spp., Candidiasis, metal nanoparticles.
Effective start/end date11/3/2111/10/22

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Main Funding Source

  • Competitive Funds
  • Small Amount


  • Bogotá D.C.


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