Perinatal asphyxia is the leading cause of death in the first week of life worldwide, children who suffer this complication and survive may present neurological disorders of different levels of commitment that affect their personal and social development. Death figures for this health problem have decreased significantly; however, according to the 2010 World Health Organization (PAHO) report, perinatal asphyxia is the cause of 29% of infant deaths in Latin American and Caribbean countries 2. It is also necessary to know the extent of neurological damage suffered by these children. To this end, a pilot study was carried out at the Hospital Universitario Mayor Mederi in Bogotá, in which the concentration of a metabolic marker of brain damage, the S100B protein, was determined in the serum of 60 healthy newborns, with the aim of analyzing its association with birth weight, gestational age and diagnosis. The results did not show significant differences between this marker and the variables analyzed, which may be associated with the small number of patients; however, they have laid the foundations for the development of a study that includes several hospitals in Bogotá and especially the determination of this marker in newborns diagnosed with hypoxia in the perinatal period, which will provide information on the degree of the alteration they may have at the cerebral level and contribute to better evolutionary management with the application of intervention measures in early stages of life.
asfixia perinatal, marcadores, proteína S100B
|Effective start/end date||5/31/13 → 5/15/14|
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):
Main Funding Source
- Installed Capacity (Academic Unit)
- Bogotá D.C.
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