Multiomic Approach to the Study of Autoimmune Diseases

Autoimmune diseases constitute a group of conditions characterized by loss of immune tolerance, resulting in local or systemic tissue damage. With a significant prevalence of about 5% in the general population, these diseases present considerable challenges due to their high rate of comorbidity, chronic and incurable nature.

Despite advances in the field of autoimmunity, the pathophysiology of these diseases remains partially understood, with many mechanisms to be elucidated, including hereditary and environmental factors, the biological role of genetic polymorphisms and their relationship to immunological and clinical features.

This project aims to identify molecular patterns, potential biomarkers and key mechanisms linked to autoimmunity. In doing so, it seeks not only to advance the scientific understanding of these diseases, but also to contribute to the development of more accurate diagnostic tools, patient stratification strategies and, ultimately, personalized therapies.

GENERAL OBJECTIVE

To comprehensively understand the molecular and functional basis of autoimmune diseases through a multi-omic approach.

SPECIFIC OBJECTIVES

-Identify molecular alterations in genomic, transcriptomic, proteomic, immunolomic and metabolomic profiles associated with autoimmune diseases.
-Search for and validate biomarkers that can be used for early diagnosis, patient stratification and monitoring of autoimmune disease progression.
-To develop methods and approaches to integrate multi-omics data enabling the understanding of the mechanisms of autoimmunity.