Project Details
Description
To determine through a comprehensive systematic review and meta-analysis of the published evidence, the risk associated with estrogen use in women with SLE and the risk of SLE in the general population according to their exposure.
Exogenous estrogen administration has been used clinically in women for the treatment of symptoms associated with menopause, as hormone replacement therapy (HRT), in hormonal contraception, and in ovulation induction to control infertility. There are conflicting data regarding whether exposure to exogenous sex hormones [oral contraceptives (OCs) and hormone replacement therapy (HRT)] can affect the natural history of individuals with systemic lupus erythematosus (SLE). The aim of this work is to determine, through a systematic review and meta-analysis, the risks associated with estrogen use in women with SLE, as well as the association of estrogens with the development of SLE.
Exogenous estrogen administration has been used clinically in women for the treatment of symptoms associated with menopause, as hormone replacement therapy (HRT), in hormonal contraception, and in ovulation induction to control infertility. There are conflicting data regarding whether exposure to exogenous sex hormones [oral contraceptives (OCs) and hormone replacement therapy (HRT)] can affect the natural history of individuals with systemic lupus erythematosus (SLE). The aim of this work is to determine, through a systematic review and meta-analysis, the risks associated with estrogen use in women with SLE, as well as the association of estrogens with the development of SLE.
| Status | Finished |
|---|---|
| Effective start/end date | 5/1/12 → 1/30/13 |
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):
Main Funding Source
- Installed Capacity (Academic Unit)
Location
- South America
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