Project Details
Description
The original description of Acute Respiratory Distress Syndrome (ARDS) dates back more than 50 years, however it was not until 1994 when clearer diagnostic criteria were established and applicable in clinical practice, this definition was updated in 2012, in what we know as the "Berlin Criteria" seeking to overcome the limitations of previous definitions.
Multiple observational studies have been developed with estimates of ARDS incidence varying widely, ranging from 2 to 19% of all patients admitted to intensive care. In 2016, the "Large observational study to UNderstand the Globlal Impact of Severe Acute Respiratory Failure (LUNG SAFE) Study" was conducted, which showed an overall incidence of 10% ARDS in all intensive care admissions, with mortality greater than 40% in severe cases.
The Berlin criteria for ARDS require a drop in oxygenation indices with values of Arterial Oxygen Pressure (Pa02) over Inspired Oxygen Fraction (FiO2) below 300 and in severe cases below 100, and also gives a recommendation to adjust this parameter for sites with altitude greater than 1000 metres above sea level by multiplying Pa02/FiO2 by the result of the site's barometric pressure (BP) determined above 760 mmHg (BP at sea level).
In late 2019, a new coronavirus, called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), caused an epidemic of acute respiratory disease in Wuhan, China. The World Health Organisation (WHO) classified this disease as Coronavirus 2019 (COVID-19). In different series, mortality varies from 2.3 to 7.2 %. The most severe manifestation of this disease is ARDS with a mortality of 50% in this population.
This recommendation has no references based on clinical trials, nor how the outcomes are in this group of patients. This study aims to establish the incidence of ARDS, describe oxygenation indices and clinical outcomes in patients with ARDS in the intensive care unit of the Hospital Universitario Mayor Méderi, located in the city of Bogotá at an altitude of 2600 metres.
Multiple observational studies have been developed with estimates of ARDS incidence varying widely, ranging from 2 to 19% of all patients admitted to intensive care. In 2016, the "Large observational study to UNderstand the Globlal Impact of Severe Acute Respiratory Failure (LUNG SAFE) Study" was conducted, which showed an overall incidence of 10% ARDS in all intensive care admissions, with mortality greater than 40% in severe cases.
The Berlin criteria for ARDS require a drop in oxygenation indices with values of Arterial Oxygen Pressure (Pa02) over Inspired Oxygen Fraction (FiO2) below 300 and in severe cases below 100, and also gives a recommendation to adjust this parameter for sites with altitude greater than 1000 metres above sea level by multiplying Pa02/FiO2 by the result of the site's barometric pressure (BP) determined above 760 mmHg (BP at sea level).
In late 2019, a new coronavirus, called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), caused an epidemic of acute respiratory disease in Wuhan, China. The World Health Organisation (WHO) classified this disease as Coronavirus 2019 (COVID-19). In different series, mortality varies from 2.3 to 7.2 %. The most severe manifestation of this disease is ARDS with a mortality of 50% in this population.
This recommendation has no references based on clinical trials, nor how the outcomes are in this group of patients. This study aims to establish the incidence of ARDS, describe oxygenation indices and clinical outcomes in patients with ARDS in the intensive care unit of the Hospital Universitario Mayor Méderi, located in the city of Bogotá at an altitude of 2600 metres.
Keywords
ARDS, altitude, SARS-CoV-2
| Status | Finished |
|---|---|
| Effective start/end date | 7/1/20 → 7/1/22 |
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):
Main Funding Source
- Installed Capacity (Academic Unit)
Location
- Bogotá D.C.
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