Impact of genetic and non-genetic factors on the severity of SARS-CoV-2 infection: towards the generation of a risk prediction model in a Colombian population.

Project: Research Project

Project Details


Currently, according to WHO reports, there are more than 30 million confirmed cases and about 950,000 deaths globally caused by COVID-19. In Colombia, there have been nearly 850,000 confirmed cases and 26,556 deaths to date (as of October 4, 2020). SARS-CoV-2 infection is characterized by diverse clinical manifestations, ranging from asymptomatic individuals to critically ill patients, some of whom die from complications arising from the infection.
Specific risk factors for the development of severe disease include cardiovascular disorders, diabetes mellitus, arterial hypertension and chronic pulmonary disease, among others.
In addition to these factors, the impact of genetic polymorphisms of the ACE2 and ACE1 receptors and the 3p21.31 locus on the clinical response to COVID-19 has recently been documented. The consequence of some genetic variants has been associated with increased receptor expression potentially favoring the virus-host cell affinity relationship. Given the impact of the COVID-19 pandemic on health, the national economy and society, it is important to develop proposals such as the present one, which proposes the generation of a risk prediction model related to SARS-CoV2. The integration of genetic (analysis of 3 SNPs of the ACE1,ACE2 genes and of the 3p21.31 locus) and non-genetic factors will allow the generation of a tool that will be of scientific interest and of social appropriation of knowledge.


SARS-CoV-2, COVID-19, genetic susceptibility, ACE1, ACE2, 3p21.31, severity risk, risk prediction

Commitments / Obligations

Consolidation of the research activities of the CIGGUR seedbed, through the participation of us as students in the generation, execution and dissemination of a translational research project and the creation of a predictive algorithm where genetic and non-genetic risk factors are considered, and their association with the severity of infection by SARSCoV-2.2. Training in molecular biology and genetic techniques which will allow us to develop practical skills in the laboratory and analysis of genetic results. These activities will be focused on genotyping by Sanger sequencing of polymorphisms 8790G>A (rs2285666) of the ACE2 gene, Insertion/Deletion (rs4646994) of the ACE1 gene and the intergenic variant of locus 3p21. 31 (rs11385942) in 120 patients with a diagnosis of COVID-19 performed by RT-PCR or SARS-CoV-2 Ag test.3. Estimation of the allelic and genotypic frequency of ACE1, ACE2 and 3p21.31 polymorphisms in the described population.4. Carrying out bioinformatics and programming practices in R for the creation of an application that allows the use of the algorithm proposed in the study.5. Preparation of an article suitable for publication.

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Effective start/end date3/1/213/31/22

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Main Funding Source

  • Competitive Funds
  • Incubator


  • Bogotá D.C.


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