Functional and cognitive characterization of a population of centenarians who consult in a high complexity hospital in Bogotá between 2019 and 2020

Project: Research project

Project Details

Description

The progressive aging of the Colombian population with the consequent increase in morbidity and mortality, economic and public health costs, makes it necessary to develop preventive and therapeutic strategies aimed at allowing people to develop healthy aging.

Centenarians, people with 100 years or more, are not a homogeneous population. Cohort studies of centenarians have found a wide variability in both physical and cognitive functional levels. Identifying centenarians, or older people who are likely to have low functional levels, is necessary in order to implement preventive strategies to decrease the decline and risk of complications associated with aging.
The development of biomarkers of aging is a fundamental part for the identification of people at risk of presenting pathologies associated with aging and for the evaluation of the impact of interventions that change the course of aging.
Recently it has been found that the erythrocyte distribution width (Red blood cell distribution width - RDW) increases with age and that it has a high predictive power of mortality from cardiovascular causes, coronary artery disease and cancer, among other causes of death. An increase in RDW is also associated with increased incidence of cardiovascular disease, heart failure, peripheral vascular disease, atrial fibrillation, stroke, and cancer.
The high predictive value of WDR for a wide range of negative health characteristics in the elderly may be in part because it is influenced by fundamental pathways of aging and may reflect the end result of adding them all up. In a centenary, it is expected that all these pathways are interacting, making it the ideal age group to test the potential association between a biomarker and the characteristics of aging.
The present research raises the study of the centenary population of the Mederi Major University Hospital (HUM) with the aim of studying the possible association between RDW and cognitive and functional status in centenaries of a third level hospital in Bogota, Colombia from 2019-2020. To our knowledge this type of analysis has not been previously performed.
For this, we propose an observational, analytical cross-sectional study. The centenarians attending the emergency department or outpatient clinic of the HUM between November 2019 and July 2020 will be investigated until the sample size is completed. Each patient will be compared with a patient of 80 years and older. To each one, a functional and a cognitive survey will be applied. Variables related to the width of erythrocyte distribution and other hematological variables will be analyzed through the surveys to look for possible associations.
This project is nested in a project under development entitled "Functional and transcriptome characterization of lymphocytes from a centenary population of a high complexity hospital in Bogotá, Colombia, 2019-2022". This is the first phase, in which a cohort of centenarians will be built, to which clinical history will be recorded, interviews and physical examinations will be carried out to evaluate cognitive and functional status as well as to identify the characteristics of their hemogram.

Layman's description

Se busca determinar si personas con longevidad extendida tienen un comportamienot particular con respecto al ancho de disrtibucion eritrocitaria y si esto se relaciona con niveles de funcionalidad mental y fisica
StatusActive
Effective start/end date1/1/2012/31/20

Main Funding Source

  • National