Effects of exercise intensity on hepatic metabolism and cardiovascular health in overweight/obese adolescents: Factorial controlled study. HEPAFIT Project

  • Correa-Bautista, Jorge Enrique (CoI)
  • Ramirez-Velez , Robinsón (PI)
  • Izquierdo, Mikel (PI)
  • González-Ruíz, Katherine (PI)
  • González-Jiménez, Emilio (PI)
  • valle, Jacqueline Schmidt Río (PI)
  • Lobelo, Felipe (PI)
  • Dominguez-Sanchez, Maria Andrea (PI)
  • Cañete, Jorge (CoI)
  • García-Hermoso, Antonio (PI)

Project: Research Project

Project Details


In the world it is estimated that 10% of children of school age, are overweight and a quarter of them are obese. In Colombia, the increase in rates of childhood obesity represents a priority in primary health care, so it is necessary to implement non-pharmacological intervention strategies to mitigate this problem. It has been described that the development of obesity depends not only on the balance between intake and energy expenditure, but also on the balance between white adipose tissue (WAT), as the main energy reservoir, and brown or brown adipose tissue. (BAT), specialized in energy expenditure, in the form of thermogenesis using the uncoupled mitochondrial protein 1 (UCP-1). Additionally, it has been proposed that the accumulation of fat in liver tissue is intimately linked to the increase of visceral fat, to subclinical low-grade inflammatory states and to insulin resistance. All these, physiopathological mechanisms are related to the risk of developing metabolic and vascular diseases from early ages.
Currently, the management of overweight and obesity has focused on treatments such as caloric restriction, physical exercise, and different drugs with promising results for the different metabolic adaptations that may be beneficial for individuals with excess weight. Therefore, our research hypothesis is that high intensity physical exercise will generate a reduction of fat in the liver along with benefits in liver metabolism and cardiovascular health in overweight / obese adolescents of the District of Bogotá.

For this, we intend to develop a 2x2 factorial clinical trial, masquerading simple with randomization by balanced blocks in 120 adolescents, forming 4 groups: a) Schoolchildren with conventional physical education (EFC), n = 30; b) Schoolchildren with EFC and supervised program with games of moderate intensity, n = 30; c) Schoolchildren with EFC and supervised program with high intensity games, n = 30; and d) School with EFC, supervised program with high intensity games + supervised program with games of moderate intensity. In the groups will be included overweight school (according to IOTF), between 11 and 17 years, without participation in sports extra-school activity, without medical history that discourage their participation in physical activities (clinical history, physical examination, biochemical analysis), without dietary treatment or unusual dietary habits and in the case of girls, after menarche.
In the short term, this project offers the opportunity to obtain detailed measures on the health of body composition, cardiometabolic health and liver function in children and adolescents


hepatic metabolism; health cardiovascular; exercise effects; adolescent
Short titleHEPAFIT Project
AcronymEstudio HEPAFIT
Effective start/end date2/16/162/15/19

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Main Funding Source

  • National


  • Bogotá D.C.


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