Detection of mutations in the PINK1, PARKIN and DJ1 genes in a sample of institutionalized Parkinson's disease patients in Bogotá, Colombia

Project: Research project

Description

Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease and the most common cause of Parkinsonism. It affects approximately 1% of the population over 50. This disease has a significant genetic component, particularly in cases with early onset of the disease (Before age 51). This is a pilot project to determine alterations in the PINK1, PARKIN and DJ1 genes associated with Parkinson's disease in Colombia. To determine the frequency of such alterations in an institutionalized population. For this purpose, we propose to study exons with a higher mutational index for these genes by means of molecular techniques, for example in the case of the PINK1 gene, exons 4 and 7; and in the case of PARKIN exons 2,3,7 and 8.
StatusFinished
Effective start/end date3/5/1012/31/17